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    CG3999 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41253, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG3999provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037801
    Locus tag
    Dmel_CG3999
    See related
    AllianceGenome:FB:FBgn0037801
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3999
    Summary
    Predicted to enable glycine binding activity; glycine dehydrogenase (decarboxylating) activity; and pyridoxal phosphate binding activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to be part of glycine cleavage complex. Predicted to be active in mitochondrial matrix. Is expressed in adult head; adult heart; embryonic/larval fat body; fat body/gonad primordium; and yolk nucleus. Used to study glycine encephalopathy. Human ortholog(s) of this gene implicated in glycine encephalopathy and glycine encephalopathy 1. Orthologous to human GLDC (glycine decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3999 in Genome Data Viewer
    Location:
    86A2-86A2; 3-49 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10251518..10255268)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6077240..6080990)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sirtuin 6 Neighboring gene pontin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nutritional geometry framework of sleep. Lai ML, et al. Life Sci, 2023 Mar 1. PMID 36640899
    2. Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways. Popovic R, et al. Int J Mol Sci, 2021 Apr 27. PMID 33925631, Free PMC Article
    3. Drosophila Uri, a PP1alpha binding protein, is essential for viability, maintenance of DNA integrity and normal transcriptional activity. Kirchner J, et al. BMC Mol Biol, 2008 Apr 15. PMID 18412953, Free PMC Article
    4. Genome-wide analysis of promoter architecture in Drosophila melanogaster. Hoskins RA, et al. Genome Res, 2011 Feb. PMID 21177961, Free PMC Article
    5. Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Sonn JY, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915051, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine dehydrogenase (decarboxylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine dehydrogenase (decarboxylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycine dehydrogenase (decarboxylating) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycine decarboxylation via glycine cleavage system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine decarboxylation via glycine cleavage system ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of glycine cleavage complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycine cleavage complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3999-PA
    CG3999-PB
    NP_001262456.1
    NP_649989.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10251518..10255268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141732.2 → NP_649989.1  uncharacterized protein Dmel_CG3999, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649989.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH09
      Related
      FBpp0081703
      Conserved Domains (3) summary
      COG1003
      Location:494 → 949
      GcvP2; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]
      PRK05367
      Location:35 → 981
      PRK05367; glycine dehydrogenase; Provisional
      pfam02347
      Location:40 → 464
      GDC-P; Glycine cleavage system P-protein

    2. NM_001275527.1 → NP_001262456.1  uncharacterized protein Dmel_CG3999, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262456.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH09
      Conserved Domains (3) summary
      COG1003
      Location:494 → 949
      GcvP2; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]
      PRK05367
      Location:35 → 981
      PRK05367; glycine dehydrogenase; Provisional
      pfam02347
      Location:40 → 464
      GDC-P; Glycine cleavage system P-protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH09 Q9VH09

    Gene LinkOut

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