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    prd1 pruning defect 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41425, updated on 4-Jan-2025

    Summary

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    Official Symbol
    prd1provided by FlyBase
    Official Full Name
    pruning defect 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037949
    Locus tag
    Dmel_CG17360
    See related
    AllianceGenome:FB:FBgn0037949
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH29885; CG17360; Dmel\CG17360
    Summary
    Enables small GTPase binding activity. Predicted to be involved in Golgi organization; lysosome localization; and regulation of protein localization. Located in Golgi apparatus. Orthologous to human PLEKHM2 (pleckstrin homology and RUN domain containing M2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See prd1 in Genome Data Viewer
    Location:
    86E18-86F7; 3-51 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11781131..11787014, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7606853..7612736, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene lethal (3) neo38 Neighboring gene long non-coding RNA:CR45595 Neighboring gene Histamine-gated chloride channel subunit 1 Neighboring gene SET domain binding factor Neighboring gene Chloride channel-a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prd1 associates with the clathrin adaptor α-Adaptin and the kinesin-3 Imac/Unc-104 to govern dendrite pruning in Drosophila. Zong W, et al. PLoS Biol, 2018 Aug. PMID 30142146, Free PMC Article
    2. The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic Depression. Li T, et al. J Biol Chem, 2015 Jul 17. PMID 25953899, Free PMC Article
    3. Recent progress in dendritic pruning of Drosophila C4da sensory neurons. Rui M. Open Biol, 2024 Jul. PMID 39046196, Free PMC Article
    4. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prd1, alpha-Adaptin, and Unc-104 act in a common pathway to promote dendrite pruning by down-regulating Neuroglian protein.
      Title: Prd1 associates with the clathrin adaptor α-Adaptin and the kinesin-3 Imac/Unc-104 to govern dendrite pruning in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pruning defect 1
    Names
    CG17360-PA
    CG17360-PB
    prd1-PA
    prd1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11781131..11787014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141858.2 → NP_650115.1  pruning defect 1, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR50, Q9VGI1
      Related
      FBpp0082005
      Conserved Domains (2) summary
      cd13309
      Location:1022 → 1126
      PH_SKIP; SifA and kinesin-interacting protein Pleckstrin homology (PH) domain
      pfam00169
      Location:1021 → 1119
      PH; PH domain

    2. NM_001275557.1 → NP_001262486.1  pruning defect 1, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH60, Q6NR50
      Conserved Domains (2) summary
      cd13309
      Location:998 → 1102
      PH_SKIP; SifA and kinesin-interacting protein Pleckstrin homology (PH) domain
      pfam00169
      Location:997 → 1095
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KH60 A0A0B4KH60
    Q6NR50 Q6NR50
    Q8IGG0 Q8IGG0
    Q9VGI1 Q9VGI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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