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    IA-2 IA-2 protein tyrosine phosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33277, updated on 14-Nov-2024

    Summary

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    Official Symbol
    IA-2provided by FlyBase
    Official Full Name
    IA-2 protein tyrosine phosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031294
    Locus tag
    Dmel_CG31795
    See related
    AllianceGenome:FB:FBgn0031294
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0153538.69; CG11344; CG31795; CG4355; Dmel\CG31795; ia-2; ia2; IA2; R-PTPX/1A2
    Summary
    Involved in digestive tract development and regulation of secretion. Predicted to be active in secretory granule and synapse. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; brain; midgut; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to several human genes including PTPRN2 (protein tyrosine phosphatase receptor type N2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See IA-2 in Genome Data Viewer
    Location:
    21E3-21E3; 2-1.5 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1008378..1048053, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1008378..1048053, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 2 Neighboring gene long non-coding RNA:CR44801 Neighboring gene antisense RNA:CR46486 Neighboring gene uncharacterized protein Neighboring gene germinal nascent polypeptide-associated complex alpha subunit Neighboring gene Star Neighboring gene asteroid

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish. Cai T, et al. Diabetologia, 2001 Jan. PMID 11206415
    2. A Progressive Somatic Cell Niche Regulates Germline Cyst Differentiation in the Drosophila Ovary. Shi J, et al. Curr Biol, 2021 Feb 22. PMID 33340458
    3. Complex protein interactions mediate Drosophila Lar function in muscle tissue. Kawakami J, et al. PLoS One, 2022. PMID 35622884, Free PMC Article
    4. Drosophila ia2 modulates secretion of insulin-like peptide. Kim J, et al. Comp Biochem Physiol A Mol Integr Physiol, 2008 Oct. PMID 18634898
    5. A genome-wide enhancer/suppressor screen for Dube3a interacting genes in Drosophila melanogaster. Hope KA, et al. Sci Rep, 2019 Feb 20. PMID 30787400, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables phosphatase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables protein tyrosine phosphatase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    IA-2 protein tyrosine phosphatase
    Names
    CG31795-PC
    CG31795-PD
    CG31795-PE
    IA-2 ortholog
    IA-2-PC
    IA-2-PD
    IA-2-PE
    ia2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1008378..1048053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164401.5 → NP_722672.3  IA-2 protein tyrosine phosphatase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722672.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E11, Q7YTY8
      Conserved Domains (3) summary
      smart00194
      Location:947 → 1207
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:982 → 1207
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam11548
      Location:695 → 782
      Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2

    2. NM_134718.6 → NP_608562.4  IA-2 protein tyrosine phosphatase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608562.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YTY8, Q9VPV8
      Conserved Domains (3) summary
      smart00194
      Location:960 → 1220
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:995 → 1220
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam11548
      Location:708 → 795
      Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2

    3. NM_001272922.1 → NP_001259851.1  IA-2 protein tyrosine phosphatase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259851.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PAZ4, Q7YTY8
      Conserved Domains (3) summary
      smart00194
      Location:959 → 1219
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:994 → 1219
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam11548
      Location:707 → 794
      Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PAZ4 M9PAZ4
    Q59E11 Q59E11
    Q7YTY8 Q7YTY8
    Q8MQR5 Q8MQR5
    Q9BKN7 Q9BKN7
    Q9VPV8 Q9VPV8

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