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    Hsdl2 Hydroxysteroid dehydrogenase like 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43325, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Hsdl2provided by FlyBase
    Official Full Name
    Hydroxysteroid dehydrogenase like 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0039537
    Locus tag
    Dmel_CG5590
    See related
    AllianceGenome:FB:FBgn0039537
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5590; Dmel\CG5590; HSDL2
    Summary
    Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and head epidermis primordium. Orthologous to human HSDL2 (hydroxysteroid dehydrogenase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hsdl2 in Genome Data Viewer
    Location:
    98B1-98B1; 3-94 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27677522..27679013)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23503244..23504735)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Myosin alkali light chain 1 Neighboring gene uncoordinated 80 Neighboring gene uncharacterized protein Neighboring gene Sex combs extra

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sex-dependent and sex-independent regulatory systems of size variation in natural populations. Okada H, et al. Mol Syst Biol, 2019 Nov. PMID 31777173, Free PMC Article
    2. Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling. Yin J, et al. Nat Commun, 2021 Apr 23. PMID 33893307, Free PMC Article
    3. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. O'Keefe LV, et al. Hum Mol Genet, 2011 Feb 1. PMID 21075834, Free PMC Article
    4. Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila. Hoffmann J, et al. Aging (Albany NY), 2013 Apr. PMID 23765091, Free PMC Article
    5. Characterization of the Drosophila lipid droplet subproteome. Beller M, et al. Mol Cell Proteomics, 2006 Jun. PMID 16543254

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables steroid dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydroxysteroid dehydrogenase like 2
    Names
    CG5590-PA
    Hsdl2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27677522..27679013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143321.3 → NP_651578.1  hydroxysteroid dehydrogenase like 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651578.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VB10
      Related
      FBpp0084585
      Conserved Domains (3) summary
      PRK08278
      Location:7 → 277
      PRK08278; short chain dehydrogenase; Provisional
      COG1028
      Location:5 → 245
      FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam02036
      Location:317 → 406
      SCP2; SCP-2 sterol transfer family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VB10 Q9VB10

    Gene LinkOut

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