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    Tmtc2 Transmembrane O-mannosyltransferase targeting cadherins 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33276, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmtc2provided by FlyBase
    Official Full Name
    Transmembrane O-mannosyltransferase targeting cadherins 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0028481
    Locus tag
    Dmel_CG4341
    See related
    AllianceGenome:FB:FBgn0028481
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH12144; CG4341; Dmel\CG4341; TMTC2
    Summary
    Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be active in endoplasmic reticulum membrane. Is expressed in spermatozoon. Orthologous to human TMTC2 (transmembrane O-mannosyltransferase targeting cadherins 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tmtc2 in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (922793..958098)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (922793..958098)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44061 Neighboring gene Glutamate receptor IIC Neighboring gene long non-coding RNA:CR44801 Neighboring gene antisense RNA:CR46486 Neighboring gene IA-2 protein tyrosine phosphatase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites. Eisenhaber B, et al. Biol Direct, 2021 Jan 12. PMID 33436046, Free PMC Article
    2. A genome-wide enhancer/suppressor screen for Dube3a interacting genes in Drosophila melanogaster. Hope KA, et al. Sci Rep, 2019 Feb 20. PMID 30787400, Free PMC Article
    3. A single cell genomics atlas of the Drosophila larval eye reveals distinct photoreceptor developmental timelines. Bollepogu Raja KK, et al. Nat Commun, 2023 Nov 8. PMID 37938573, Free PMC Article
    4. Protein O-mannosylation: one sugar, several pathways, many functions. Koff M, et al. Glycobiology, 2023 Dec 25. PMID 37565810, Free PMC Article
    5. Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression. Ghavi-Helm Y, et al. Nat Genet, 2019 Aug. PMID 31308546, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane O-mannosyltransferase targeting cadherins 2
    Names
    CG4341-PA
    CG4341-PC
    Tmtc2-PA
    Tmtc2-PC
    NP_001097048.2
    NP_608558.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      922793..958098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134714.5 → NP_608558.1  transmembrane O-mannosyltransferase targeting cadherins 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608558.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3X5
      Related
      FBpp0077614
      Conserved Domains (5) summary
      sd00006
      Location:602 → 630
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:636 → 668
      TPR_1; Tetratricopeptide repeat
      pfam08409
      Location:275 → 343
      DUF1736; Domain of unknown function (DUF1736)
      pfam13414
      Location:602 → 667
      TPR_11; TPR repeat
      cl21590
      Location:112 → 232
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    2. NM_001103578.3 → NP_001097048.2  transmembrane O-mannosyltransferase targeting cadherins 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097048.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYS8
      Conserved Domains (5) summary
      sd00006
      Location:572 → 600
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:606 → 638
      TPR_1; Tetratricopeptide repeat
      pfam08409
      Location:245 → 313
      DUF1736; Domain of unknown function (DUF1736)
      pfam13414
      Location:572 → 637
      TPR_11; TPR repeat
      cl21590
      Location:82 → 202
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYS8 A8DYS8
    Q9V3X5.1 Q9V3X5

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