U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    S-Lap2 Sperm-Leucylaminopeptidase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326209, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    S-Lap2provided by FlyBase
    Official Full Name
    Sperm-Leucylaminopeptidase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0052351
    Locus tag
    Dmel_CG32351
    See related
    AllianceGenome:FB:FBgn0052351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.85; BcDNA:LP03301; CG32351; Dmel\CG32351; FBgn0052351; Lap CG32351; S-Lap 2; S-LAP 2
    Summary
    Predicted to enable manganese ion binding activity. Predicted to be involved in proteolysis. Predicted to be located in major mitochondrial derivative. Predicted to be active in cytoplasm. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See S-Lap2 in Genome Data Viewer
    Location:
    66D8-66D8; 3-26 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8619888..8622091)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8612988..8615191)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sperm-Leucylaminopeptidase 1 Neighboring gene GTPase activating protein, SECIS-dependent read-through Neighboring gene Z band alternatively spliced PDZ-motif protein 66 Neighboring gene Cell division cycle 6 Neighboring gene Cuticular protein 66D

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Recurrent gene co-amplification on Drosophila X and Y chromosomes. Ellison C, et al. PLoS Genet, 2019 Jul. PMID 31329593, Free PMC Article
    2. Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm. Dorus S, et al. BMC Genomics, 2011 Apr 5. PMID 21466698, Free PMC Article
    3. Sperm-Leucylaminopeptidases are required for male fertility as structural components of mitochondrial paracrystalline material in Drosophila melanogaster sperm. Laurinyecz B, et al. PLoS Genet, 2019 Feb. PMID 30802236, Free PMC Article
    4. Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development. Blagden SP, et al. Dev Biol, 2009 Oct 1. PMID 19631203
    5. Genomic and functional evolution of the Drosophila melanogaster sperm proteome. Dorus S, et al. Nat Genet, 2006 Dec. PMID 17099714

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables metalloaminopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables metalloaminopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in major mitochondrial derivative ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Sperm-Leucylaminopeptidase 2
    Names
    CG32351-PA
    S-Lap2-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8619888..8622091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168282.2 → NP_729394.1  Sperm-Leucylaminopeptidase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSM7
      Related
      FBpp0076363
      Conserved Domains (2) summary
      PRK00913
      Location:53 → 539
      PRK00913; multifunctional aminopeptidase A; Provisional
      cd00433
      Location:52 → 538
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSM7 Q9VSM7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools