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    aru arouser [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33268, updated on 2-Nov-2024

    Summary

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    Official Symbol
    aruprovided by FlyBase
    Official Full Name
    arouserprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029095
    Locus tag
    Dmel_CG4276
    See related
    AllianceGenome:FB:FBgn0029095
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4276; Dmel\CG4276; EPS8L3
    Summary
    Predicted to enable actin binding activity. Involved in several processes, including memory; olfactory behavior; and response to ethanol. Located in synapse. Is expressed in adult abdomen; adult brain; adult head; adult thorax; and organism. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102 and autosomal recessive nonsyndromic deafness 106. Orthologous to several human genes including EPS8L1 (EPS8 signaling adaptor L1) and EPS8L2 (EPS8 signaling adaptor L2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See aru in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (861849..868354, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (861849..868354, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45345 Neighboring gene mir-375 stem loop Neighboring gene uncharacterized protein Neighboring gene dribble Neighboring gene Phosphatase 1 nuclear targeting subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The arouser EPS8L3 gene is critical for normal memory in Drosophila. LaFerriere H, et al. PLoS One, 2011. PMID 21818402, Free PMC Article
    2. An inexpensive, scalable behavioral assay for measuring ethanol sedation sensitivity and rapid tolerance in Drosophila. Sandhu S, et al. J Vis Exp, 2015 Apr 15. PMID 25939022, Free PMC Article
    3. Finding a place and leaving a mark in memory formation. Sitaraman D, et al. J Neurogenet, 2020 Mar. PMID 31878832, Free PMC Article
    4. Learning to collaborate: bringing together behavior and quantitative genomics. Williams-Simon PA, et al. J Neurogenet, 2020 Mar. PMID 31920134
    5. Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing. Chan HY, et al. Mol Biol Cell, 2001 May. PMID 11359931, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in memory IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in olfactory behavior IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synapse structure or activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arouser
    Names
    CG4276-PA
    CG4276-PC
    CG4276-PD
    EPS8L3
    aru-PA
    aru-PC
    aru-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      861849..868354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078725.3 → NP_523449.2  arouser, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523449.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3Z9, Q9VPU7
      Related
      FBpp0077695
      Conserved Domains (2) summary
      cd11764
      Location:664 → 717
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:55 → 188
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    2. NM_164395.1 → NP_722665.1  arouser, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722665.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3Z9, Q9VPU7
      Related
      FBpp0077696, FBtr0078032
      Conserved Domains (2) summary
      cd11764
      Location:664 → 717
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:55 → 188
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    3. NM_164393.1 → NP_722663.1  arouser, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMF7, Q8IPW1
      Related
      FBpp0077697, FBtr0078033
      Conserved Domains (2) summary
      cd11764
      Location:691 → 744
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:82 → 215
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPW1 Q8IPW1
    Q8T8Q9 Q8T8Q9
    Q9U3Z9 Q9U3Z9
    Q9VPU7 Q9VPU7

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