bs blistered [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bsprovided by FlyBase
Official Full Name: blisteredprovided by FlyBase
Primary source: FLYBASE:FBgn0004101
Locus tag: Dmel_CG3411
See related: AllianceGenome:FB:FBgn0004101
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ba; Bs; BS; bs/Dsrf; bs/DSRF; CG3411; D-SRF; Dmel\CG3411; DmSRF; Drf; dsrf; dSRF; DSrf; DSRF; DSrf/bs; Group IIc; l(2)03267; Mal; pruned/DSRF; px; Serf; srf; Srf; SRF
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and DNA-binding transcription factor binding activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including instar larval or pupal development; short-term memory; and terminal branching, open tracheal system. Located in nucleus. Is expressed in several structures, including gut section; larval muscle cell; organism subdivision; presumptive embryonic/larval central nervous system; and wing vein. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 60C6-60C7; 2-106 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24342861..24376473)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20230384..20263996)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

bsAS, an antisense long non-coding RNA, essential for correct wing development through regulation of blistered/DSRF isoform usage.
Title: bsAS, an antisense long non-coding RNA, essential for correct wing development through regulation of blistered/DSRF isoform usage.
Our results indicate that DSRF acts as an amplifying step to sustain the progression of terminal branch elongation of the trachael system
Title: The Drosophila homologue of SRF acts as a boosting mechanism to sustain FGF-induced terminal branching in the tracheal system.
Border cell migration requires the activity of serum response factor and nuclear accumulation of MAL-D is induced by cell stretching.
Title: Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration.
Data describe a myocardin-related transcription factor from Drosophila, DMRTF, which is shares homology with mammalian myocardin and MRTFs and stimulates the activity of Drosophila serum response factor.
Title: A myocardin-related transcription factor regulates activity of serum response factor in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0269 (e-PCR)
- UniSTS:23962

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 24353484-24361787 mobile_element_type = transposon:roo{}883

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in instar larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in pupal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: blistered

Names: CG3411-PA; CG3411-PB; CG3411-PC; SRF; balloon; blistered/DSRF; blistered/Drosophila serum response factor; bs-PA; bs-PB; bs-PC; drosophila serum response; drosophila serum response factor; factor; pruned; serum response factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24342861..24376473

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299908.1 → NP_001286837.1 blistered, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286837.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24535, Q9W182

UniProtKB/TrEMBL

A0A0B4LGL8

Conserved Domains (1) summary

cd00266
Location:166 → 247

MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...
NM_001144279.3 → NP_001137751.1 blistered, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137751.1

Status: REVIEWED

UniProtKB/TrEMBL

B7YZQ0

Conserved Domains (1) summary

cd00266
Location:166 → 247

MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...
NM_166667.3 → NP_726438.1 blistered, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726438.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24535, Q9W182

UniProtKB/TrEMBL

A0A0B4LGL8

Related

FBpp0072178

Conserved Domains (1) summary

cd00266
Location:166 → 247

MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...