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    dbe dribble [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33269, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dbeprovided by FlyBase
    Official Full Name
    dribbleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020305
    Locus tag
    Dmel_CG4258
    See related
    AllianceGenome:FB:FBgn0020305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4258; DBE; Dmel\CG4258; l(2)k05428; l(2)k06708
    Summary
    Enables RNA binding activity. Involved in rRNA processing. Located in nucleolus and nucleoplasm. Part of ribonucleoprotein complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to human KRR1 (KRR1 small subunit processome component homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See dbe in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (868673..869857, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (868673..869857, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene arouser Neighboring gene Phosphatase 1 nuclear targeting subunit Neighboring gene uncharacterized protein Neighboring gene neither inactivation nor afterpotential A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene drive that results in addiction to a temperature-sensitive version of an essential gene triggers population collapse in Drosophila. Oberhofer G, et al. Proc Natl Acad Sci U S A, 2021 Dec 7. PMID 34845012, Free PMC Article
    2. Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble. Yiu CP, et al. Biochem Biophys Res Commun, 2006 Apr 28. PMID 16542639
    3. Crystallization and preliminary crystallographic analysis of the central domain of Drosophila Dribble, a protein that is essential for ribosome biogenesis. Cheng TC, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 May 1. PMID 20445256, Free PMC Article
    4. Identification and characterization of kraken, a gene encoding a putative hydrolytic enzyme in Drosophila melanogaster. Edwin Chan HY, et al. Gene, 1998 Nov 19. PMID 9831651
    5. Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing. Chan HY, et al. Mol Biol Cell, 2001 May. PMID 11359931, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystals of DBE(16-197) were grown by the sitting-drop vapour-diffusion method at 289 K using ammonium phosphate as a precipitant.
      Title: Crystallization and preliminary crystallographic analysis of the central domain of Drosophila Dribble, a protein that is essential for ribosome biogenesis.
    2. The presence of structural disorder is an important feature of DBE that facilitates the protein to interact with RNAs in the nucleolus.
      Title: Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dribble
    Names
    CG4258-PA
    dbe-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      868673..869857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057892.4 → NP_477240.1  dribble [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477240.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02394, Q9VPU8
      Related
      FBpp0077694
      Conserved Domains (2) summary
      smart00322
      Location:140 → 190
      KH; K homology RNA-binding domain
      COG1094
      Location:34 → 212
      Krr1; rRNA processing protein Krr1/Pno1, contains KH domain [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPU8.1 Q9VPU8

    Gene LinkOut

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