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    ssp2 short spindle 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ssp2provided by FlyBase
    Official Full Name
    short spindle 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036389
    Locus tag
    Dmel_CG9028
    See related
    AllianceGenome:FB:FBgn0036389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9028; Dmel\CG9028; sentin; Sentin; Ssp2
    Summary
    Involved in microtubule cytoskeleton organization and spindle attachment to meiosis I kinetochore. Located in meiotic spindle pole. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ssp2 in Genome Data Viewer
    Location:
    70C7-70C9; 3-41 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13965203..13973067)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13958303..13966167)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Meiotic central spindle Neighboring gene Nuclear export factor 3 Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 70 cognate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin. Li W, et al. J Cell Biol, 2012 Nov 26. PMID 23185033, Free PMC Article
    2. EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells. Li W, et al. J Cell Biol, 2011 Jun 13. PMID 21646401, Free PMC Article
    3. The microtubule catastrophe promoter Sentin delays stable kinetochore-microtubule attachment in oocytes. Głuszek AA, et al. J Cell Biol, 2015 Dec 21. PMID 26668329, Free PMC Article
    4. TOG Proteins Are Spatially Regulated by Rac-GSK3β to Control Interphase Microtubule Dynamics. Trogden KP, et al. PLoS One, 2015. PMID 26406596, Free PMC Article
    5. Five factors can reconstitute all three phases of microtubule polymerization dynamics. Moriwaki T, et al. J Cell Biol, 2016 Nov 7. PMID 27799364, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    • transcript and protein products are distinct from overlapping gene

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spindle attachment to meiosis I kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome HDA PubMed 
    located_in meiotic spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    short spindle 2
    Names
    CG9028-PA
    CG9028-PC
    sentin
    short spindle
    ssp2-PA
    ssp2-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13965203..13973067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300136.1 → NP_001287065.1  short spindle 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q32KC5, Q9VUA5
      Conserved Domains (1) summary
      PHA03247
      Location:676 → 965
      PHA03247; large tegument protein UL36; Provisional

    2. NM_140415.4 → NP_648672.1  short spindle 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q32KC5, Q9VUA5
      Related
      FBpp0075501
      Conserved Domains (1) summary
      PHA03247
      Location:676 → 965
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUA5 Q9VUA5

    Gene LinkOut

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