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    CG4896 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33305, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4896provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031319
    Locus tag
    Dmel_CG4896
    See related
    AllianceGenome:FB:FBgn0031319
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg4896; Dmel\CG4896
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in TARP syndrome; colorectal cancer; lung adenocarcinoma; and lung cancer. Orthologous to human RBM10 (RNA binding motif protein 10) and RBM5 (RNA binding motif protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4896 in Genome Data Viewer
    Location:
    21F2-21F2; 2-2 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1177690..1182454)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1177690..1182454)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene charon Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA-guanine transglycosylase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Direct measurement of pervasive weak repression by microRNAs and their role at the network level. Ma F, et al. BMC Genomics, 2018 May 15. PMID 29764374, Free PMC Article
    2. Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster. Holloway AK, et al. Genome Res, 2008 Oct. PMID 18583644, Free PMC Article
    3. Striking circadian neuron diversity and cycling of Drosophila alternative splicing. Wang Q, et al. Elife, 2018 Jun 4. PMID 29863472, Free PMC Article
    4. Network analyses reveal novel aspects of ALS pathogenesis. Sanhueza M, et al. PLoS Genet, 2015 Mar. PMID 25826266, Free PMC Article
    5. The genetic architecture of odor-guided behavior in Drosophila melanogaster. Anholt RR, et al. Behav Genet, 2001 Jan. PMID 11529271

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4896-PD
    CG4896-PG
    CG4896-PI
    CG4896-PJ
    CG4896-PK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1177690..1182454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258901.2 → NP_001245830.2  uncharacterized protein Dmel_CG4896, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245830.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDC4
      Conserved Domains (1) summary
      cl17169
      Location:211 → 252
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_164409.4 → NP_722689.4  uncharacterized protein Dmel_CG4896, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722689.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHG7, Q8IPW5, Q8IPW6
      Conserved Domains (6) summary
      smart00547
      Location:294 → 318
      ZnF_RBZ; Zinc finger domain
      cd12313
      Location:341 → 427
      RRM1_RRM2_RBM5_like; RNA recognition motif 1 and 2 in RNA-binding protein 5 (RBM5) and similar proteins
      cd12561
      Location:209 → 289
      RRM1_RBM5_like; RNA recognition motif 1 in RNA-binding protein 5 (RBM5) and similar proteins
      sd00029
      Location:296 → 315
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam01585
      Location:880 → 920
      G-patch; G-patch domain
      cd16162
      Location:560 → 615
      OCRE_RBM5_like; OCRE domain found in RNA-binding protein RBM5, RBM10, and similar proteins

    3. NM_001258902.2 → NP_001245831.1  uncharacterized protein Dmel_CG4896, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245831.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDC4
      Conserved Domains (1) summary
      cl17169
      Location:211 → 252
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_134739.6 → NP_608583.5  uncharacterized protein Dmel_CG4896, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608583.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023GRW3, Q8IHG7
      Related
      FBpp0077633
      Conserved Domains (7) summary
      smart00547
      Location:296 → 320
      ZnF_RBZ; Zinc finger domain
      cd12313
      Location:343 → 429
      RRM1_RRM2_RBM5_like; RNA recognition motif 1 and 2 in RNA-binding protein 5 (RBM5) and similar proteins
      cd12561
      Location:211 → 291
      RRM1_RBM5_like; RNA recognition motif 1 in RNA-binding protein 5 (RBM5) and similar proteins
      sd00029
      Location:298 → 317
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam01585
      Location:882 → 922
      G-patch; G-patch domain
      pfam08648
      Location:91 → 158
      DUF1777; Protein of unknown function (DUF1777)
      cd16162
      Location:562 → 617
      OCRE_RBM5_like; OCRE domain found in RNA-binding protein RBM5, RBM10, and similar proteins

    5. NM_001272931.1 → NP_001259860.1  uncharacterized protein Dmel_CG4896, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259860.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDX7
      Conserved Domains (1) summary
      cl17169
      Location:211 → 252
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A023GRW3 A0A023GRW3
    M9NDC4 M9NDC4
    M9PDX7 M9PDX7
    Q6NQZ3 Q6NQZ3
    Q8IHG7 Q8IHG7
    Q8IPW6 Q8IPW6

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