U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pen-2 presenilin enhancer [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 251430, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pen-2provided by FlyBase
    Official Full Name
    presenilin enhancerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053198
    Locus tag
    Dmel_CG33198
    See related
    AllianceGenome:FB:FBgn0053198
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-AE003800.1; CG33198; Dmel\CG33198; dPen-2; dPEN2; Pen-2; PEN2
    Summary
    Involved in amyloid-beta formation; positive regulation of endopeptidase activity; and proteolysis. Located in late endosome and recycling endosome. Part of gamma-secretase complex. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pen-2 in Genome Data Viewer
    Location:
    55C2-55C2; 2-85 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18277439..18278762)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14164944..14166267)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44421 Neighboring gene Otefin Neighboring gene scribbler Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate. Isoo N, et al. J Biol Chem, 2007 Apr 27. PMID 17329245
    2. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. Niimura M, et al. J Biol Chem, 2005 Apr 1. PMID 15644323
    3. Gamma-secretase is a functional component of phagosomes. Jutras I, et al. J Biol Chem, 2005 Oct 28. PMID 16103123
    4. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. Hu Y, et al. J Cell Biol, 2003 May 26. PMID 12771124, Free PMC Article
    5. A reporter for amyloid precursor protein gamma-secretase activity in Drosophila. Guo M, et al. Hum Mol Genet, 2003 Oct 15. PMID 12944419

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in Notch receptor processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Notch receptor processing, ligand-dependent IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amyloid-beta formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amyloid-beta formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of gamma-secretase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-secretase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-secretase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    presenilin enhancer
    Names
    CG33198-PA
    CG33198-PB
    pen-2-PA
    pen-2-PB
    presenilin enhancer 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18277439..18278762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299637.1 → NP_001286566.1  presenilin enhancer, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286566.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E6Z8, Q86BE9, Q8MUT4
      UniProtKB/TrEMBL
      A0A0B4LFM5
      Conserved Domains (1) summary
      pfam10251
      Location:7 → 99
      PEN-2; Presenilin enhancer-2 subunit of gamma secretase

    2. NM_176221.4 → NP_788401.2  presenilin enhancer, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788401.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E6Z8, Q86BE9, Q8MUT4
      UniProtKB/TrEMBL
      A0A0B4LFM5
      Related
      FBpp0088783
      Conserved Domains (1) summary
      pfam10251
      Location:7 → 99
      PEN-2; Presenilin enhancer-2 subunit of gamma secretase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFM5 A0A0B4LFM5
    Q86BE9.3 Q86BE9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous