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    prtp pretaporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32124, updated on 27-Dec-2024

    Summary

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    Official Symbol
    prtpprovided by FlyBase
    Official Full Name
    pretaporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030329
    Locus tag
    Dmel_CG1837
    See related
    AllianceGenome:FB:FBgn0030329
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey253; CG1837; Dmel\CG1837; p47; Prtp
    Summary
    Predicted to enable protein disulfide isomerase activity. Involved in apoptotic cell clearance and positive regulation of apoptotic cell clearance. Located in endoplasmic reticulum. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval fat body; and head mesoderm. Orthologous to human TXNDC5 (thioredoxin domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prtp in Genome Data Viewer
    Location:
    10D7-10D7; 1-35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11716756..11719894)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11610789..11613927)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mir-9370 stem loop Neighboring gene amun Neighboring gene long non-coding RNA:CR45618 Neighboring gene Transport and Golgi organization 10 Neighboring gene uncharacterized protein Neighboring gene inaF-D Neighboring gene inaF-B Neighboring gene inaF-C Neighboring gene inaF-A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear localization of Pretaporter in Drosophila melanogaster third-instar larvae salivary gland and its deficiency-associated nuclear phenotype. Silvera MC, et al. MicroPubl Biol, 2024. PMID 39205673, Free PMC Article
    2. Role of NPxY motif in Draper-mediated apoptotic cell clearance in Drosophila. Fujita Y, et al. Drug Discov Ther, 2012 Dec. PMID 23337816
    3. Apoptosis-dependent externalization and involvement in apoptotic cell clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila. Okada R, et al. J Biol Chem, 2012 Jan 27. PMID 22158613, Free PMC Article
    4. Complement-Related Regulates Autophagy in Neighboring Cells. Lin L, et al. Cell, 2017 Jun 29. PMID 28666117, Free PMC Article
    5. Fragile X mental retardation protein coordinates neuron-to-glia communication for clearance of developmentally transient brain neurons. Song C, et al. Proc Natl Acad Sci U S A, 2023 Mar 21. PMID 36920921, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pretaporter
    Names
    CG1837-PA
    CG1837-PB
    CG1837-PC
    CG1837-PD
    pret-a-porter
    prtp-PA
    prtp-PB
    prtp-PC
    prtp-PD
    NP_001188583.1
    NP_001188584.1
    NP_001259460.1
    NP_572742.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11716756..11719894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201654.2 → NP_001188583.1  pretaporter, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188583.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PGX2, Q9VYV3
      Conserved Domains (2) summary
      cd03005
      Location:167 → 267
      PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
      TIGR01130
      Location:39 → 409
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    2. NM_001201655.2 → NP_001188584.1  pretaporter, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188584.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PGX2, Q9VYV3
      Conserved Domains (2) summary
      cd03005
      Location:167 → 267
      PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
      TIGR01130
      Location:39 → 409
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    3. NM_132514.3 → NP_572742.1  pretaporter, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572742.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PGX2, Q9VYV3
      Related
      FBpp0073396
      Conserved Domains (2) summary
      cd03005
      Location:167 → 267
      PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
      TIGR01130
      Location:39 → 409
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    4. NM_001272531.1 → NP_001259460.1  pretaporter, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259460.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYV3
      Conserved Domains (3) summary
      cd03005
      Location:104 → 204
      PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
      TIGR01130
      Location:2 → 346
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:2 → 77
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYV3.2 Q9VYV3

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