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    Cpes Ceramide phosphoethanolamine synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37782, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cpesprovided by FlyBase
    Official Full Name
    Ceramide phosphoethanolamine synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025335
    Locus tag
    Dmel_CG4585
    See related
    AllianceGenome:FB:FBgn0025335
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-60Ab; ces; CG4585; CK00282; CPE; cpes; CPES; dCCS4; Dmel\CG4585; UD2
    Summary
    Enables ceramide phosphoethanolamine synthase activity. Involved in ceramide phosphoethanolamine biosynthetic process. Located in Golgi apparatus. Is expressed in adult head. Used to study photosensitive epilepsy. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Cpes in Genome Data Viewer
    Location:
    60A5-60A5; 2-105 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23862962..23865398, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19750485..19752921, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene benign gonial cell neoplasm Neighboring gene Partner of Y14 and Mago Neighboring gene TAR DNA-binding protein-43 homolog Neighboring gene uncharacterized protein Neighboring gene Mitochondrial trifunctional protein beta subunit Neighboring gene ken and barbie

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants. Kunduri G, et al. Proc Natl Acad Sci U S A, 2018 Sep 18. PMID 30185559, Free PMC Article
    2. Wrapping axons in mammals and Drosophila: Different lipids, same principle. Murate M, et al. Biochimie, 2020 Nov. PMID 32800899
    3. Neuronal function and dysfunction of Drosophila dTDP. Lin MJ, et al. PLoS One, 2011. PMID 21673800, Free PMC Article
    4. Developmental inhibition of miR-iab8-3p disrupts mushroom body neuron structure and adult learning ability. Busto GU, et al. Dev Biol, 2016 Nov 15. PMID 27634569, Free PMC Article
    5. Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen. Vacaru AM, et al. J Biol Chem, 2013 Apr 19. PMID 23449981, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ceramide phosphoethanolamine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ceramide phosphoethanolamine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ceramide phosphoethanolamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ceramide phosphoethanolamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ceramide phosphoethanolamine synthase
    Names
    CG4585-PA
    CG4585-PB
    CG4585-PC
    CG4585-PD
    CPE synthase
    Cpes-PA
    Cpes-PB
    Cpes-PC
    Cpes-PD
    undefined 2
    NP_001286788.1
    NP_001286789.1
    NP_001286790.1
    NP_477376.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23862962..23865398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058028.5 → NP_477376.1  ceramide phosphoethanolamine synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477376.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77475
      UniProtKB/TrEMBL
      A0A0B4LGC8
      Related
      FBpp0072136
      Conserved Domains (1) summary
      COG0558
      Location:136 → 237
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

    2. NM_001299859.1 → NP_001286788.1  ceramide phosphoethanolamine synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286788.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77475
      UniProtKB/TrEMBL
      A0A0B4LGC8
      Conserved Domains (1) summary
      COG0558
      Location:136 → 237
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

    3. NM_001299860.1 → NP_001286789.1  ceramide phosphoethanolamine synthase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286789.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77475
      UniProtKB/TrEMBL
      A0A0B4LGC8
      Conserved Domains (1) summary
      COG0558
      Location:136 → 237
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

    4. NM_001299861.1 → NP_001286790.1  ceramide phosphoethanolamine synthase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286790.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77475
      UniProtKB/TrEMBL
      A0A0B4LGC8
      Conserved Domains (1) summary
      COG0558
      Location:136 → 237
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGC8 A0A0B4LGC8
    O77475.1 O77475

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