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    kkv krotzkopf verkehrt [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45884, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kkvprovided by FlyBase
    Official Full Name
    krotzkopf verkehrtprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001311
    Locus tag
    Dmel_CG2666
    See related
    AllianceGenome:FB:FBgn0001311
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    blimp; Blimp; CG2666; chitin synthase; ChSB; CS-1; CS-1/kkv; DmCS-1; DmeCHS1; DmeChSB; Dmel\CG2666; Kkv; l(3)82Fh
    Summary
    Enables chitin synthase activity. Involved in several processes, including chitin biosynthetic process; epithelial tube morphogenesis; and respiratory system development. Located in apical plasma membrane and cytoplasm. Is expressed in several structures, including embryonic epipharynx; embryonic hypopharynx; epithelium; gut section; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kkv in Genome Data Viewer
    Location:
    83A1-83A1; 3-47.5 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5378093..5392866, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1203815..1218588, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene 7B2 Neighboring gene transfer RNA:Arginine-TCG 4-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 83a Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of chitin in exoskeleton morphogenesis in Drosophila melanogaster. Moussian B, et al. J Morphol, 2005 Apr. PMID 15747378
    2. Fatty acid binding protein is required for chitin biosynthesis in the wing of Drosophila melanogaster. Chen J, et al. Insect Biochem Mol Biol, 2022 Oct. PMID 36165873
    3. Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of action on chitin biosynthesis. Douris V, et al. Proc Natl Acad Sci U S A, 2016 Dec 20. PMID 27930336, Free PMC Article
    4. SERCA interacts with chitin synthase and participates in cuticular chitin biogenesis in Drosophila. Zhu W, et al. Insect Biochem Mol Biol, 2022 Jun. PMID 35525402
    5. Cortical instability drives periodic supracellular actin pattern formation in epithelial tubes. Hannezo E, et al. Proc Natl Acad Sci U S A, 2015 Jul 14. PMID 26077909, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila.
      Title: A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila.
    2. Choline transporter-like protein 2 interacts with chitin synthase 1 and is involved in insect cuticle development.
      Title: Choline transporter-like protein 2 interacts with chitin synthase 1 and is involved in insect cuticle development.
    3. when Kkv and Exp/Reb are co-expressed in the ectoderm, they promote chitin deposition, even in tissues normally devoid of this polysaccharide.
      Title: Deciphering the genetic programme triggering timely and spatially-regulated chitin deposition.
    4. Encodes chitin synthase, maps to Chromosome 3 near the centromere.
      Title: Genetic control of cuticle formation during embryonic development of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitin synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables chitin synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based embryonic cuticle biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic epithelial tube formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in liquid clearance, open tracheal system HMP PubMed 
    involved_in lumen formation, open tracheal system HMP PubMed 
    involved_in lumen formation, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube diameter, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube length, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in trachea morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    krotzkopf verkehrt
    Names
    CG2666-PA
    CG2666-PC
    CG2666-PD
    chitin Syn1
    chitin synthase
    chitin synthase 1
    chitin synthase B
    chitin synthase-1
    kkv-PA
    kkv-PC
    kkv-PD
    krotzkopf-verkehrt
    short of breath
    NP_524233.1
    NP_730928.2
    NP_996152.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5378093..5392866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169052.3 → NP_730928.2  krotzkopf verkehrt, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730928.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7P4
      Conserved Domains (1) summary
      cd04190
      Location:583 → 904
      Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin

    2. NM_079509.3 → NP_524233.1  krotzkopf verkehrt, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524233.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPN4
      Related
      FBpp0078442
      Conserved Domains (1) summary
      cd04190
      Location:583 → 904
      Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin

    3. NM_206430.3 → NP_996152.1  krotzkopf verkehrt, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996152.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPN4
      Conserved Domains (1) summary
      cd04190
      Location:583 → 904
      Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPN4 Q8IPN4
    Q8MQN8 Q8MQN8
    Q8WQ84 Q8WQ84
    Q961Q5 Q961Q5
    Q9GTZ7 Q9GTZ7
    Q9I7P4 Q9I7P4

    Gene LinkOut

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