U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SIFa SIFamide [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3346202, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SIFaprovided by FlyBase
    Official Full Name
    SIFamideprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053527
    Locus tag
    Dmel_CG33527
    See related
    AllianceGenome:FB:FBgn0053527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33527; Dmel\CG33527; Drm-IFa; Drm-SIFa; IFa; IFAMIDE; Neb-LFamide; SIF; SIFR
    Summary
    Enables neuropeptide receptor binding activity and receptor ligand activity. Involved in several processes, including mating behavior, sex discrimination; negative regulation of female receptivity; and neuropeptide signaling pathway. Predicted to be located in extracellular space. Is expressed in several structures, including adult brain; adult pars intercerebralis; larval central nervous system; neurosecretory cell of pars intercerebralis; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SIFa in Genome Data Viewer
    Location:
    60D5-60D5; 2-107 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24577566..24578143, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20465089..20465666, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene unconventional prefoldin RPB5 interactor Neighboring gene TFIIF-interacting CTD phosphatase Neighboring gene uncharacterized protein Neighboring gene Start1 Neighboring gene uncharacterized protein Neighboring gene piopio

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. SIFamide is a highly conserved neuropeptide: a comparative study in different insect species. Verleyen P, et al. Biochem Biophys Res Commun, 2004 Jul 23. PMID 15219831
    2. Optogenetic activation of SIFamide (SIFa) neurons induces a complex sleep-promoting effect in the fruit fly Drosophila melanogaster. Huang H, et al. Physiol Behav, 2021 Oct 1. PMID 34175361, Free PMC Article
    3. SIFamide and SIFamide receptor defines a novel neuropeptide signaling to promote sleep in Drosophila. Park S, et al. Mol Cells, 2014 Apr. PMID 24658384, Free PMC Article
    4. The neuropeptide SIFamide modulates sexual behavior in Drosophila. Terhzaz S, et al. Biochem Biophys Res Commun, 2007 Jan 12. PMID 17126293
    5. SIFamide acts on fruitless neurons to modulate sexual behavior in Drosophila melanogaster. Sellami A, et al. Peptides, 2015 Dec. PMID 26469541

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We demonstrate that thermogenetic manipulations of PI neurons expressing the neuropeptide SIFamide (SIFa) as well as mutations of the SIFa gene degrade feeding:fasting rhythms. In contrast, manipulations of a nearby population of PI neurons that express the Drosophila insulin-like peptides (DILPs) affect total food consumption but leave feeding rhythms intact
      Title: A circadian output center controlling feeding:fasting rhythms in Drosophila.
    2. SIFamide acts on fruitless neurons to modulate sexual behavior in Drosophila melanogaster.
      Title: SIFamide acts on fruitless neurons to modulate sexual behavior in Drosophila melanogaster.
    3. signaling promotes sleep
      Title: SIFamide and SIFamide receptor defines a novel neuropeptide signaling to promote sleep in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables neuropeptide receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mating behavior, sex discrimination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of female receptivity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    SIFamide
    Names
    AYRKPPFNGSLFamide
    CG33527-PB
    IFamide
    Neb-LFamide
    SIFa-PB
    neuropeptide AYRKPPFNGSIFamide
    neuropeptide IFamide

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24577566..24578143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259567.2 → NP_001246496.1  SIFamide [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246496.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E6Z0, A8E728, B3DMR1, Q6IGX9, Q8IA34
      UniProtKB/TrEMBL
      A0A1B2AKW2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IGX9.1 Q6IGX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools