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    trn tartan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39491, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trnprovided by FlyBase
    Official Full Name
    tartanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010452
    Locus tag
    Dmel_CG11280
    See related
    AllianceGenome:FB:FBgn0010452
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0024/05; 0641/17; anon-EST:fe2B1; CG11280; CT31487; Dmel\CG11280; Tartan; Trn
    Summary
    Involved in branch fusion, open tracheal system; larval salivary gland morphogenesis; and motor neuron axon guidance. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including eye photoreceptor cell; gut section; head epidermis primordium; imaginal disc; and larval optic anlage. Orthologous to human LRRN2 (leucine rich repeat neuronal 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See trn in Genome Data Viewer
    Location:
    70A1-70A1; 3-40 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13114271..13118077)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13107371..13111177)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45749 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44554 Neighboring gene uncharacterized protein Neighboring gene sneaky

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila synapse formation: regulation by transmembrane protein with Leu-rich repeats, CAPRICIOUS. Shishido E, et al. Science, 1998 Jun 26. PMID 9641918
    2. Inference of Cell Mechanics in Heterogeneous Epithelial Tissue Based on Multivariate Clone Shape Quantification. Tsuboi A, et al. Front Cell Dev Biol, 2017. PMID 28824908, Free PMC Article
    3. Boundary formation in the Drosophila wing: functional dissection of Capricious and Tartan. Milán M, et al. Dev Dyn, 2005 Jul. PMID 15830355
    4. The Selector Gene apterous and Notch Are Required to Locally Increase Mechanical Cell Bond Tension at the Drosophila Dorsoventral Compartment Boundary. Michel M, et al. PLoS One, 2016. PMID 27552097, Free PMC Article
    5. Different temporal requirements for tartan and wingless in the formation of contractile interfaces at compartmental boundaries. Sharrock TE, et al. Development, 2022 Nov 1. PMID 36178136, Free PMC Article

    See all (115) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identified the cell surface receptor Tartan (Trn) as a candidate substrate for the neuronal RPTP Ptp52F by using a modified two-hybrid screen with a substrate-trapping mutant of Ptp52F as "bait"
      Title: The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F.
    2. caps and tartan proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation
      Title: Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map.
    3. Capricious and Tartan contribute to the adhesive properties of the cells in the morphogenetic furrow and that this regulated adhesion participates in the control of spacing ommatidial clusters
      Title: Modulation of Drosophila retinal epithelial integrity by the adhesion proteins capricious and tartan.
    4. Provides permissive substrate for the migrating embryonic tracheal cells during network formation.
      Title: Distinct functions of the leucine-rich repeat transmembrane proteins capricious and tartan in the Drosophila tracheal morphogenesis.
    5. extracellular domains of Capricious and Tartan may work as ligands of an unknown dorsal cell surface protein, and required to transduce a signal necessary for the establishment of the DV boundary
      Title: Boundary formation in the Drosophila wing: functional dissection of Capricious and Tartan.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in branch fusion, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in larval salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tartan
    Names
    CG11280-PA
    CG11280-PB
    TARTAN
    anon-fast-evolving-2B1
    tarten
    trn-PA
    trn-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13114271..13118077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079331.4 → NP_524055.2  tartan, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524055.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24250, Q9VU51
      Related
      FBpp0075624
      Conserved Domains (3) summary
      cd00116
      Location:129 → 421
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:84 → 107
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:132 → 190
      LRR_8; Leucine rich repeat

    2. NM_001274867.1 → NP_001261796.1  tartan, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261796.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFH7, Q24250
      Conserved Domains (3) summary
      cd00116
      Location:129 → 421
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:84 → 107
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:132 → 190
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFH7 M9PFH7
    Q24250 Q24250
    Q9VU51 Q9VU51

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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