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    CG17760 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36385, updated on 27-Dec-2024

    Summary

    Official Symbol
    CG17760provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033756
    Locus tag
    Dmel_CG17760
    See related
    AllianceGenome:FB:FBgn0033756
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD21019; Dmel\CG17760; Galphaq; GNAQ/11/14
    Summary
    Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in labellum. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; autosomal dominant hypocalcemia 2; congestive heart failure; familial hypocalciuric hypercalcemia 2; and familial multiple nevi flammei. Orthologous to human GNA11 (G protein subunit alpha 11) and GNAQ (G protein subunit alpha q). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See CG17760 in Genome Data Viewer
    Location:
    49B9-49B10; 2-67 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12625808..12628619)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8513313..8516124)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene G protein alpha subunit q Neighboring gene uncharacterized protein Neighboring gene muskelin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG17760-PB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12625808..12628619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043074.2NP_001036539.1  uncharacterized protein Dmel_CG17760 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036539.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQV5
      Conserved Domains (2) summary
      cd00066
      Location:34347
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:13351
      G_alpha; G protein alpha subunit