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    CG41099 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355072, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG41099provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039955
    Locus tag
    Dmel_CG41099
    See related
    AllianceGenome:FB:FBgn0039955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GM10035; CG17416; CG17419; Dmel\CG41099; FBgn0039955; GM10035; Rabankyrin
    Summary
    Predicted to enable metal ion binding activity. Involved in embryonic morphogenesis; endocytosis; and epithelial cell morphogenesis. Located in vacuole. Is expressed in adult head; head mesoderm; organism; trunk mesoderm; and ventral ectoderm. Orthologous to human ANKFY1 (ankyrin repeat and FYVE domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG41099 in Genome Data Viewer
    Location:
    81F5-81F5; 3-47.1 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (3846729..3868401)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3RHet NW_001848858.1 (1684395..1706067, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Translocase of the inner mitochondrial membrane 17b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutamine:fructose-6-phosphate aminotransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMFP: a non-negative matrix factorization based preselection method to increase accuracy of identifying mRNA isoforms from RNA-seq data. Ye Y, et al. BMC Genomics, 2016 Jan 11. PMID 26818007, Free PMC Article
    2. Tubular endocytosis drives remodelling of the apical surface during epithelial morphogenesis in Drosophila. Fabrowski P, et al. Nat Commun, 2013. PMID 23921440, Free PMC Article
    3. Vav independently regulates synaptic growth and plasticity through distinct actin-based processes. Park HG, et al. J Cell Biol, 2022 Oct 3. PMID 35976098, Free PMC Article
    4. Predicting host dependency factors of pathogens in Drosophila melanogaster using machine learning. Aromolaran O, et al. Comput Struct Biotechnol J, 2021. PMID 34471501, Free PMC Article
    5. BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis. Kim N, et al. Nat Commun, 2019 Feb 8. PMID 30737382, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG41099-PB
    CG41099-PC
    CG41099-PD
    CG41099-PE
    D-Rabankyrin
    Rabankyrin-5
    rabankyrin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      3846729..3868401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001110981.2 → NP_001104451.1  uncharacterized protein Dmel_CG41099, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104451.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y582
      Conserved Domains (7) summary
      smart00225
      Location:73 → 164
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG0666
      Location:750 → 975
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:818 → 942
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd15728
      Location:1052 → 1114
      FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
      pfam00651
      Location:65 → 162
      BTB; BTB/POZ domain
      pfam12796
      Location:577 → 668
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:820 → 853
      ANK; ANK repeat [structural motif]

    2. NM_001110980.2 → NP_001104450.2  uncharacterized protein Dmel_CG41099, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104450.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y583, Q7PLP4
      Conserved Domains (7) summary
      smart00225
      Location:62 → 153
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG0666
      Location:739 → 964
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:807 → 931
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd15728
      Location:1041 → 1103
      FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
      pfam00651
      Location:54 → 151
      BTB; BTB/POZ domain
      pfam12796
      Location:566 → 657
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:809 → 842
      ANK; ANK repeat [structural motif]

    3. NM_001015360.3 → NP_001015360.1  uncharacterized protein Dmel_CG41099, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015360.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y583, Q7PLP4
      Conserved Domains (7) summary
      smart00225
      Location:62 → 153
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG0666
      Location:739 → 964
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:807 → 931
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd15728
      Location:1041 → 1103
      FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
      pfam00651
      Location:54 → 151
      BTB; BTB/POZ domain
      pfam12796
      Location:566 → 657
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:809 → 842
      ANK; ANK repeat [structural motif]

    4. NM_001015359.3 → NP_001015359.1  uncharacterized protein Dmel_CG41099, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015359.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7PLP5
      Conserved Domains (7) summary
      smart00225
      Location:75 → 166
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG0666
      Location:752 → 977
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:820 → 944
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd15728
      Location:1054 → 1116
      FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
      pfam00651
      Location:67 → 164
      BTB; BTB/POZ domain
      pfam12796
      Location:579 → 670
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:822 → 855
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8Y582 A8Y582
    Q5BI36 Q5BI36
    Q7PLP4 Q7PLP4
    Q7PLP5 Q7PLP5
    Q8SY24 Q8SY24

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