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    P58IPK P58IPK [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41161, updated on 2-Nov-2024

    Summary

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    Official Symbol
    P58IPKprovided by FlyBase
    Official Full Name
    P58IPKprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037718
    Locus tag
    Dmel_CG8286
    See related
    AllianceGenome:FB:FBgn0037718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:SD05682; CG8286; dIPK; Dmel\CG8286; SD05682.5prime
    Summary
    Predicted to enable misfolded protein binding activity and protein-folding chaperone binding activity. Predicted to be involved in protein folding in endoplasmic reticulum. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval garland cell; embryonic/larval midgut primordium; gut section; and visceral mesoderm derivative. Orthologous to human DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See P58IPK in Genome Data Viewer
    Location:
    85D27-85D27; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9586942..9589581)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5412664..5415303)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Son RNA binding protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene bocksbeutel Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates. Deo A, et al. Sci Rep, 2024 Sep 6. PMID 39242711, Free PMC Article
    2. Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Park SY, et al. Genetics, 2014 Feb. PMID 24281154, Free PMC Article
    3. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Hollien J, et al. Science, 2006 Jul 7. PMID 16825573
    4. The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress. Kim AY, et al. BMC Genomics, 2015 Apr 23. PMID 25903460, Free PMC Article
    5. Thermoprotection of synaptic transmission in a Drosophila heat shock factor mutant is accompanied by increased expression of Hsp83 and DnaJ-1. Neal SJ, et al. Physiol Genomics, 2006 May 16. PMID 16595740

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates.
      Title: Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    P58IPK
    Names
    CG8286-PA
    P58IPK-PA
    inhibitor of protein kinases

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9586942..9589581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141659.4 → NP_649916.1  P58IPK [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649916.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHA8
      Related
      FBpp0081552
      Conserved Domains (6) summary
      COG0484
      Location:395 → 485
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:43 → 71
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:396 → 460
      DnaJ; DnaJ domain
      pfam00515
      Location:113 → 144
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:78 → 142
      TPR_11; TPR repeat
      pfam14559
      Location:167 → 234
      TPR_19; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHA8 Q9VHA8

    Gene LinkOut

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