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    Cog7 component of oligomeric golgi complex 7 [ Mus musculus (house mouse) ]

    Gene ID: 233824, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cog7provided by MGI
    Official Full Name
    component of oligomeric golgi complex 7provided by MGI
    Primary source
    MGI:MGI:2685013
    See related
    Ensembl:ENSMUSG00000034951 AllianceGenome:MGI:2685013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm167; 5630400E24Rik
    Summary
    Predicted to be involved in several processes, including Golgi vesicle transport; protein localization to Golgi apparatus; and protein stabilization. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be part of Golgi transport complex. Is expressed in lung; metanephros; pancreas; submandibular gland; and testis. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIe. Orthologous to human COG7 (component of oligomeric golgi complex 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 17.2), kidney adult (RPKM 15.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cog7 in Genome Data Viewer
    Location:
    7 F2; 7 65.09 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (121522059..121580940, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (121922836..121981719, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene sodium channel, nonvoltage-gated 1 gamma Neighboring gene STARR-seq mESC enhancer starr_20067 Neighboring gene predicted gene, 36848 Neighboring gene STARR-seq mESC enhancer starr_20068 Neighboring gene sodium channel, nonvoltage-gated 1 beta Neighboring gene STARR-seq mESC enhancer starr_20069 Neighboring gene STARR-positive B cell enhancer ABC_E10471 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 2 Neighboring gene glutamyl-tRNA synthetase 2, mitochondrial Neighboring gene ubiquitin family domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Golgi transport complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    conserved oligomeric Golgi complex subunit 7
    Names
    COG complex subunit 7
    NP_001028490.2
    XP_006507762.2
    XP_006507763.2
    XP_030098374.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033318.3 → NP_001028490.2  conserved oligomeric Golgi complex subunit 7

      See identical proteins and their annotated locations for NP_001028490.2

      Status: VALIDATED

      Source sequence(s)
      AK154693
      Consensus CDS
      CCDS21805.1
      UniProtKB/Swiss-Prot
      Q3U3L7, Q3UM29
      UniProtKB/TrEMBL
      A0A0R4J0Q9
      Related
      ENSMUSP00000058990.8, ENSMUST00000057576.8
      Conserved Domains (1) summary
      pfam10191
      Location:2 → 767
      COG7; Golgi complex component 7 (COG7)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      121522059..121580940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242514.2 → XP_030098374.1  conserved oligomeric Golgi complex subunit 7 isoform X3

      UniProtKB/Swiss-Prot
      Q3U3L7, Q3UM29
      Conserved Domains (1) summary
      pfam10191
      Location:2 → 745
      COG7; Golgi complex component 7 (COG7)

    2. XM_006507700.4 → XP_006507763.2  conserved oligomeric Golgi complex subunit 7 isoform X2

      UniProtKB/Swiss-Prot
      Q3U3L7, Q3UM29
      Conserved Domains (1) summary
      pfam10191
      Location:2 → 757
      COG7; Golgi complex component 7 (COG7)

    3. XM_006507699.4 → XP_006507762.2  conserved oligomeric Golgi complex subunit 7 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3L7, Q3UM29
      Conserved Domains (1) summary
      pfam10191
      Location:2 → 779
      COG7; Golgi complex component 7 (COG7)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UM29.1 GenPept UniProtKB/Swiss-Prot:Q3UM29

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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