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    Efnb2 ephrin B2 [ Mus musculus (house mouse) ]

    Gene ID: 13642, updated on 9-Dec-2024

    Summary

    Official Symbol
    Efnb2provided by MGI
    Official Full Name
    ephrin B2provided by MGI
    Primary source
    MGI:MGI:105097
    See related
    Ensembl:ENSMUSG00000001300 AllianceGenome:MGI:105097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Epl5; ELF-2; Eplg5; Htk-L; Lerk5; LERK-5; NLERK-1
    Summary
    Enables signaling receptor binding activity. Involved in several processes, including adherens junction organization; positive regulation of cardiac muscle cell differentiation; and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including negative regulation of keratinocyte proliferation; positive regulation of aorta morphogenesis; and vasculature development. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma; colorectal carcinoma; and esophagus squamous cell carcinoma. Orthologous to human EFNB2 (ephrin B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 20.3), colon adult (RPKM 11.2) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Efnb2 in Genome Data Viewer
    Location:
    8 A1.1; 8 3.42 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (8667235..8711242, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (8617235..8661242, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31135 Neighboring gene peroxiredoxin 3 pseudogene Neighboring gene VISTA enhancer mm985 Neighboring gene STARR-seq mESC enhancer starr_20661 Neighboring gene predicted gene, 31463 Neighboring gene STARR-seq mESC enhancer starr_20662 Neighboring gene RIKEN cDNA 4921522P10 gene Neighboring gene arginine and glutamate rich 1 Neighboring gene microRNA 7654

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (20)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ephrin receptor binding  
    enables ephrin receptor binding  
    enables ephrin receptor binding  
    enables protein binding PubMed 
    enables signaling receptor binding PubMed 
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell costimulation PubMed 
    involved_in adherens junction organization PubMed 
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    involved_in axon guidance  
    involved_in blood vessel morphogenesis  
    acts_upstream_of_or_within blood vessel morphogenesis PubMed 
    involved_in cell adhesion  
    involved_in cell adhesion  
    involved_in cell differentiation  
    involved_in cell migration involved in sprouting angiogenesis  
    involved_in cell migration involved in sprouting angiogenesis  
    involved_in cellular response to lipopolysaccharide  
    involved_in ephrin receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    acts_upstream_of keratinocyte proliferation PubMed 
    acts_upstream_of_or_within lymph vessel development PubMed 
    acts_upstream_of_or_within negative regulation of keratinocyte proliferation PubMed 
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of neuron projection development  
    acts_upstream_of_or_within nephric duct morphogenesis PubMed 
    acts_upstream_of_or_within positive regulation of aorta morphogenesis PubMed 
    involved_in positive regulation of cardiac muscle cell differentiation PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in presynapse assembly  
    involved_in presynapse assembly  
    involved_in regulation of chemotaxis  
    involved_in regulation of chemotaxis  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    acts_upstream_of_or_within venous blood vessel morphogenesis PubMed 
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in adherens junction  
    located_in dendrite  
    located_in dendrite  
    is_active_in glutamatergic synapse  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density membrane PubMed 
    is_active_in presynaptic membrane  
    located_in presynaptic membrane  
    is_active_in presynaptic membrane  

    General protein information

    Preferred Names
    ephrin-B2
    Names
    EPH-related receptor tyrosine kinase ligand 5
    HTK ligand

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368299.1NP_001355228.1  ephrin-B2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC138368, AC161867
    2. NM_010111.6NP_034241.2  ephrin-B2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034241.2

      Status: VALIDATED

      Source sequence(s)
      AC138368, AC161867
      Consensus CDS
      CCDS22090.1
      UniProtKB/Swiss-Prot
      P52800
      UniProtKB/TrEMBL
      Q3V1E0, Q4FJM3
      Related
      ENSMUSP00000001319.8, ENSMUST00000001319.15
      Conserved Domains (1) summary
      cd10426
      Location:32168
      Ephrin-B_Ectodomain; Ectodomain of Ephrin B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      8667235..8711242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242036.3XP_011240338.1  ephrin-B2 isoform X1

      Conserved Domains (1) summary
      cd10426
      Location:44168
      Ephrin-B_Ectodomain; Ectodomain of Ephrin B
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