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    Wfdc3 WAP four-disulfide core domain 3 [ Mus musculus (house mouse) ]

    Gene ID: 71856, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wfdc3provided by MGI
    Official Full Name
    WAP four-disulfide core domain 3provided by MGI
    Primary source
    MGI:MGI:1923897
    See related
    Ensembl:ENSMUSG00000076434 AllianceGenome:MGI:1923897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700015L13Rik; 1700127F16Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; epididymis; and lung. Orthologous to human WFDC3 (WAP four-disulfide core domain 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 25.7) and genital fat pad adult (RPKM 2.2) See more
    Orthologs
    NEW
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    Genomic context

    See Wfdc3 in Genome Data Viewer
    Location:
    2 H3; 2 85.27 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164573222..164587914, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164731226..164745994, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serine protease inhibitor, Kunitz type 4 Neighboring gene serine protease inhibitor, Kunitz type 5 Neighboring gene deoxynucleotidyltransferase, terminal, interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_06333 Neighboring gene STARR-positive B cell enhancer ABC_E417 Neighboring gene ubiquitin-conjugating enzyme E2C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    WAP four-disulfide core domain protein 3
    Names
    putative protease inhibitor WAP14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418734.1NP_001405663.1  WAP four-disulfide core domain protein 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL591127
      UniProtKB/Swiss-Prot
      Q14AE4
    2. NM_001418735.1NP_001405664.1  WAP four-disulfide core domain protein 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL591127
      UniProtKB/Swiss-Prot
      Q14AE4
    3. NM_027961.2NP_082237.1  WAP four-disulfide core domain protein 3 precursor

      See identical proteins and their annotated locations for NP_082237.1

      Status: VALIDATED

      Source sequence(s)
      AL591127
      Consensus CDS
      CCDS17053.1
      UniProtKB/Swiss-Prot
      Q14AE4
      Related
      ENSMUSP00000099385.4, ENSMUST00000103096.10
      Conserved Domains (1) summary
      pfam00095
      Location:2358
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RNA

    1. NR_184809.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591127
      Related
      ENSMUST00000109328.8
    2. NR_184810.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591127
      Related
      ENSMUST00000130227.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164573222..164587914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500193.3XP_006500256.1  WAP four-disulfide core domain protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006500256.1

      UniProtKB/Swiss-Prot
      Q14AE4
      Conserved Domains (1) summary
      pfam00095
      Location:2358
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    2. XM_036162576.1XP_036018469.1  WAP four-disulfide core domain protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q14AE4
      Conserved Domains (1) summary
      pfam00095
      Location:2358
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    3. XM_030252094.1XP_030107954.1  WAP four-disulfide core domain protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q14AE4
      Conserved Domains (1) summary
      pfam00095
      Location:2358
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'