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    Rbpjl recombination signal binding protein for immunoglobulin kappa J region-like [ Mus musculus (house mouse) ]

    Gene ID: 19668, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbpjlprovided by MGI
    Official Full Name
    recombination signal binding protein for immunoglobulin kappa J region-likeprovided by MGI
    Primary source
    MGI:MGI:1196616
    See related
    Ensembl:ENSMUSG00000017007 AllianceGenome:MGI:1196616
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RBP-L; Rbpsuhl
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of DNA-templated transcription. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including foregut-midgut junction; genitourinary system; limb mesenchyme; lung; and neural tube. Orthologous to human RBPJL (recombination signal binding protein for immunoglobulin kappa J region like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 40.4), small intestine adult (RPKM 29.8) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rbpjl in Genome Data Viewer
    Location:
    2 H3; 2 85.16 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164244996..164257368)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164403081..164415448)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene seminal vesicle secretory protein 5 Neighboring gene microRNA 7678 Neighboring gene STARR-seq mESC enhancer starr_06324 Neighboring gene secretory leukocyte peptidase inhibitor Neighboring gene matrilin 4 Neighboring gene STARR-positive B cell enhancer ABC_E6015 Neighboring gene STARR-positive B cell enhancer ABC_E4517 Neighboring gene STARR-positive B cell enhancer ABC_E6016 Neighboring gene STARR-seq mESC enhancer starr_06326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164266728-164266915 Neighboring gene syndecan 4 Neighboring gene STARR-seq mESC enhancer starr_06330 Neighboring gene STARR-positive B cell enhancer ABC_E7884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164286295-164286478 Neighboring gene SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) Neighboring gene transformation related protein 53 target 5 Neighboring gene dysbindin domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    General protein information

    Preferred Names
    recombining binding protein suppressor of hairless-like protein
    Names
    RBP-J kappa-like
    transcription factor RBP-L

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009036.1NP_033062.1  recombining binding protein suppressor of hairless-like protein

      See identical proteins and their annotated locations for NP_033062.1

      Status: PROVISIONAL

      Source sequence(s)
      Y10926
      Consensus CDS
      CCDS17035.1
      UniProtKB/Swiss-Prot
      O08674
      UniProtKB/TrEMBL
      Q3V2I2
      Related
      ENSMUSP00000017151.2, ENSMUST00000017151.2
      Conserved Domains (3) summary
      cd01176
      Location:379475
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:205357
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:67203
      LAG1-DNAbind; LAG1, DNA binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164244996..164257368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248825.2XP_030104685.1  recombining binding protein suppressor of hairless-like protein isoform X2

      Conserved Domains (2) summary
      pfam09270
      Location:205250
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:67199
      LAG1-DNAbind; LAG1, DNA binding
    2. XM_036159748.1XP_036015641.1  recombining binding protein suppressor of hairless-like protein isoform X1

      Conserved Domains (3) summary
      cd01176
      Location:276372
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:129254
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:196
      LAG1-DNAbind; LAG1, DNA binding