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    Matn4 matrilin 4 [ Mus musculus (house mouse) ]

    Gene ID: 17183, updated on 9-Dec-2024

    Summary

    Official Symbol
    Matn4provided by MGI
    Official Full Name
    matrilin 4provided by MGI
    Primary source
    MGI:MGI:1328314
    See related
    Ensembl:ENSMUSG00000016995 AllianceGenome:MGI:1328314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    matrilin-4
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within response to axon injury. Located in collagen-containing extracellular matrix. Part of matrilin complex. Is expressed in several structures, including brain; heart; respiratory system; sensory organ; and skeletal system. Orthologous to human MATN4 (matrilin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 116.8), lung adult (RPKM 38.5) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Matn4 in Genome Data Viewer
    Location:
    2 H3; 2 85.16 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164231313..164247080, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164389393..164405160, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene seminal vesicle secretory protein 5 Neighboring gene microRNA 7678 Neighboring gene STARR-seq mESC enhancer starr_06324 Neighboring gene secretory leukocyte peptidase inhibitor Neighboring gene STARR-positive B cell enhancer ABC_E6015 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region-like Neighboring gene STARR-positive B cell enhancer ABC_E4517 Neighboring gene STARR-positive B cell enhancer ABC_E6016 Neighboring gene STARR-seq mESC enhancer starr_06326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164266728-164266915 Neighboring gene syndecan 4 Neighboring gene STARR-seq mESC enhancer starr_06330 Neighboring gene STARR-positive B cell enhancer ABC_E7884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164286295-164286478 Neighboring gene SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) Neighboring gene transformation related protein 53 target 5 Neighboring gene dysbindin domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252563.1NP_001239492.1  matrilin-4 precursor

      See identical proteins and their annotated locations for NP_001239492.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK041073, AL590429, BC036558
      Consensus CDS
      CCDS17034.1
      UniProtKB/Swiss-Prot
      O89029, O89030, Q9QWS3
      UniProtKB/TrEMBL
      F2Z3U4
      Related
      ENSMUSP00000099393.2, ENSMUST00000103104.2
      Conserved Domains (2) summary
      cd01475
      Location:33255
      vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...
      pfam14670
      Location:262297
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    2. NM_013592.4NP_038620.2  matrilin-4 precursor

      See identical proteins and their annotated locations for NP_038620.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK041073, AL590429
      Consensus CDS
      CCDS17034.1
      UniProtKB/Swiss-Prot
      O89029, O89030, Q9QWS3
      UniProtKB/TrEMBL
      F2Z3U4
      Related
      ENSMUSP00000099392.4, ENSMUST00000103103.10
      Conserved Domains (2) summary
      cd01475
      Location:33255
      vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...
      pfam14670
      Location:262297
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164231313..164247080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)