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    Zfyve26 zinc finger, FYVE domain containing 26 [ Mus musculus (house mouse) ]

    Gene ID: 211978, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfyve26provided by MGI
    Official Full Name
    zinc finger, FYVE domain containing 26provided by MGI
    Primary source
    MGI:MGI:1924767
    See related
    Ensembl:ENSMUSG00000066440 AllianceGenome:MGI:1924767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm893; mKIAA0321; 4930465A13; 9330197E15Rik; A630028O16Rik
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity and protein kinase binding activity. Acts upstream of or within lysosome organization. Predicted to be located in early endosome; late endosome; and lysosome. Predicted to be active in centrosome and midbody. Is expressed in central nervous system; retina inner nuclear layer; and retina outer nuclear layer. Used to study hereditary spastic paraplegia 15. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 15. Orthologous to human ZFYVE26 (zinc finger FYVE-type containing 26). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 5.9), placenta adult (RPKM 5.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfyve26 in Genome Data Viewer
    Location:
    12 C3; 12 35.51 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (79279120..79343102, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (79232346..79296323, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11514 Neighboring gene retinol dehydrogenase 11 Neighboring gene STARR-seq mESC enhancer starr_32594 Neighboring gene retinol dehydrogenase 12 Neighboring gene STARR-positive B cell enhancer ABC_E920 Neighboring gene STARR-positive B cell enhancer ABC_E4030 Neighboring gene STARR-positive B cell enhancer ABC_E10762 Neighboring gene RAD51 paralog B Neighboring gene STARR-positive B cell enhancer ABC_E3058 Neighboring gene STARR-seq mESC enhancer starr_32597 Neighboring gene STARR-seq mESC enhancer starr_32598 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:80612777-80612978 Neighboring gene STARR-positive B cell enhancer ABC_E3059 Neighboring gene STARR-seq mESC enhancer starr_32600 Neighboring gene STARR-positive B cell enhancer ABC_E5335 Neighboring gene STARR-positive B cell enhancer ABC_E1155 Neighboring gene STARR-positive B cell enhancer ABC_E5336 Neighboring gene STARR-seq mESC enhancer starr_32602 Neighboring gene STARR-seq mESC enhancer starr_32603 Neighboring gene STARR-seq mESC enhancer starr_32604 Neighboring gene STARR-seq mESC enhancer starr_32605 Neighboring gene STARR-seq mESC enhancer starr_32606 Neighboring gene VISTA enhancer mm1393 Neighboring gene STARR-seq mESC enhancer starr_32607 Neighboring gene predicted gene, 36048 Neighboring gene predicted gene 3596

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system. Khundadze M, et al. PLoS Genet, 2013. PMID 24367272, Free PMC Article
    2. Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation. Khundadze M, et al. Autophagy, 2021 Nov. PMID 33618608, Free PMC Article
    3. Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation. Chang J, et al. J Clin Invest, 2014 Dec. PMID 25365221, Free PMC Article
    4. Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1. Pierga A, et al. PLoS Biol, 2023 Oct. PMID 37871017, Free PMC Article
    5. Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Potter PK, et al. Nat Commun, 2016 Aug 18. PMID 27534441, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased levels of lysosomal enzymes in brains of aged knockout mice further support an alteration of the lysosomal compartment upon disruption of Zfyve26
      Title: A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0321

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagosome organization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger FYVE domain-containing protein 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008550.1 → NP_001008550.1  zinc finger FYVE domain-containing protein 26

      See identical proteins and their annotated locations for NP_001008550.1

      Status: VALIDATED

      Source sequence(s)
      AK220333, BY325388
      Consensus CDS
      CCDS36481.1
      UniProtKB/Swiss-Prot
      B9EJ71, Q3TEM9, Q3V1N3, Q5DU37, Q8BY74, Q8CDR8, Q923B4
      Related
      ENSMUSP00000021547.7, ENSMUST00000021547.8
      Conserved Domains (1) summary
      cd15724
      Location:1799 → 1859
      FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      79279120..79343102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315012.3 → XP_017170501.1  zinc finger FYVE domain-containing protein 26 isoform X2

      Conserved Domains (1) summary
      cd15724
      Location:1799 → 1859
      FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

    2. XM_006515647.4 → XP_006515710.1  zinc finger FYVE domain-containing protein 26 isoform X3

      Conserved Domains (1) summary
      cd15724
      Location:1800 → 1860
      FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

    3. XM_017315011.3 → XP_017170500.1  zinc finger FYVE domain-containing protein 26 isoform X1

      Conserved Domains (1) summary
      cd15724
      Location:1800 → 1860
      FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

    4. XM_017315014.1 → XP_017170503.1  zinc finger FYVE domain-containing protein 26 isoform X5

      Conserved Domains (1) summary
      cd15724
      Location:981 → 1041
      FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

    5. XM_017315013.1 → XP_017170502.1  zinc finger FYVE domain-containing protein 26 isoform X4

      Conserved Domains (1) summary
      cd15724
      Location:982 → 1042
      FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

    RNA

    1. XR_004937482.1 RNA Sequence

    2. XR_381513.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DU37.2 GenPept UniProtKB/Swiss-Prot:Q5DU37

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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