Anxa8 annexin A8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anxa8provided by MGI
Official Full Name: annexin A8provided by MGI
Primary source: MGI:MGI:1201374
See related: Ensembl:ENSMUSG00000021950 AllianceGenome:MGI:1201374
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Anx8
Summary: Predicted to enable several functions, including actin filament binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in endosomal transport; endosome organization; and negative regulation of hydrolase activity. Predicted to be located in cytosol; late endosome membrane; and plasma membrane. Predicted to be active in cytoplasm; sarcolemma; and vesicle membrane. Is expressed in several structures, including genitourinary system; gut; respiratory system; sensory organ; and skin. Orthologous to human ANXA8 (annexin A8) and ANXA8L1 (annexin A8 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 12.6), placenta adult (RPKM 6.3) and 10 other tissues See more
Orthologs: all
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Genomic context

Location:: 14 B; 14 20.8 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (33807936..33822528)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (34085979..34100571)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.
Title: Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.
Define a distinct bone-dependent genetic program associated with terminal osteoclast differentiation and identified Anxa8 as a gene strongly induced late in osteoclast differentiation, regulating formation of the cell's characteristic actin ring.
Title: Bone matrix regulates osteoclast differentiation and annexin A8 gene expression.
Annexin A8 is involved in mouse mammary gland involution and progression of human breast cancer
Title: Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.
ANXA8 protein is most abundant in stratified epithelia of the postnatal mouse. Its location in the suprabasal layers suggests that ANXA8 may be associated with the terminal differentiation of epithelial cells in these tissues.
Title: Specific expression of annexin A8 in adult murine stratified epithelia.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Anxa8 (e-PCR), detects polymorphism
- UniSTS:472843

AI466995 (e-PCR)
- UniSTS:160372

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in endosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: annexin A8

Names: annexin 8; annexin VIII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001281845.1 → NP_001268774.1 annexin A8 isoform 2

See identical proteins and their annotated locations for NP_001268774.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC164099, AJ002390, AK009085, AK075870

Consensus CDS

CCDS70565.1

UniProtKB/TrEMBL

Q921D0

Related

ENSMUSP00000113662.2, ENSMUST00000120077.2

Conserved Domains (1) summary

pfam00191
Location:26 → 90

Annexin; Annexin
NM_013473.4 → NP_038501.2 annexin A8 isoform 1

See identical proteins and their annotated locations for NP_038501.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC164099, AJ002390, AK009085, AK075870

Consensus CDS

CCDS26932.1

UniProtKB/Swiss-Prot

O35640, Q8K2N9

Related

ENSMUSP00000022519.9, ENSMUST00000022519.15

Conserved Domains (1) summary

pfam00191
Location:26 → 90

Annexin; Annexin