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    Dbndd2 dysbindin domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 52840, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dbndd2provided by MGI
    Official Full Name
    dysbindin domain containing 2provided by MGI
    Primary source
    MGI:MGI:106562
    See related
    Ensembl:ENSMUSG00000017734 AllianceGenome:MGI:106562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nkip; R74724; D2Bwg0891e; 1110017A21Rik; 2900022J10Rik
    Summary
    Enables ATPase binding activity. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; monoatomic ion homeostasis; and neuron projection development. Is active in endoplasmic reticulum and lysosome. Is expressed in genital tubercle and urethral plate. Orthologous to human DBNDD2 (dysbindin domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 38.8), cortex adult (RPKM 22.6) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dbndd2 in Genome Data Viewer
    Location:
    2 H3; 2 85.17 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164309073..164335243)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164467153..164493323)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene matrilin 4 Neighboring gene STARR-positive B cell enhancer ABC_E6015 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region-like Neighboring gene STARR-positive B cell enhancer ABC_E4517 Neighboring gene STARR-positive B cell enhancer ABC_E6016 Neighboring gene STARR-seq mESC enhancer starr_06326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164266728-164266915 Neighboring gene syndecan 4 Neighboring gene STARR-seq mESC enhancer starr_06330 Neighboring gene STARR-positive B cell enhancer ABC_E7884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164286295-164286478 Neighboring gene SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) Neighboring gene transformation related protein 53 target 5 Neighboring gene STARR-positive B cell enhancer ABC_E9539 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class T Neighboring gene STARR-seq mESC enhancer starr_06331 Neighboring gene predicted gene, 36090

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dysbindin domain-containing protein 2
    Names
    SCF apoptosis response protein 1
    dysbindin (dystrobrevin binding protein 1) domain containing 2
    likely orthologue of H. sapiens chromosome 20 open reading frame 35

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048227.1NP_001041692.1  dysbindin domain-containing protein 2

      See identical proteins and their annotated locations for NP_001041692.1

      Status: VALIDATED

      Source sequence(s)
      AL591478, BG080686, CX241653
      Consensus CDS
      CCDS38322.1
      UniProtKB/Swiss-Prot
      Q9CRD4
      UniProtKB/TrEMBL
      Q330P7
      Related
      ENSMUSP00000104974.3, ENSMUST00000109350.9
      Conserved Domains (1) summary
      pfam04440
      Location:1280
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
    2. NM_001048228.1NP_001041693.1  dysbindin domain-containing protein 2

      See identical proteins and their annotated locations for NP_001041693.1

      Status: VALIDATED

      Source sequence(s)
      AK003735, AL591478
      Consensus CDS
      CCDS38322.1
      UniProtKB/Swiss-Prot
      Q9CRD4
      UniProtKB/TrEMBL
      Q330P7
      Related
      ENSMUSP00000104973.3, ENSMUST00000109349.9
      Conserved Domains (1) summary
      pfam04440
      Location:1280
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
    3. NM_001048229.1NP_001041694.1  dysbindin domain-containing protein 2

      See identical proteins and their annotated locations for NP_001041694.1

      Status: VALIDATED

      Source sequence(s)
      AL591478, CJ156083, CX241653
      Consensus CDS
      CCDS38322.1
      UniProtKB/Swiss-Prot
      Q9CRD4
      UniProtKB/TrEMBL
      Q330P7
      Related
      ENSMUSP00000017878.3, ENSMUST00000017878.3
      Conserved Domains (1) summary
      pfam04440
      Location:1280
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
    4. NM_026797.2NP_081073.1  dysbindin domain-containing protein 2

      See identical proteins and their annotated locations for NP_081073.1

      Status: VALIDATED

      Source sequence(s)
      AL591478, CX241653
      Consensus CDS
      CCDS38322.1
      UniProtKB/Swiss-Prot
      Q9CRD4
      UniProtKB/TrEMBL
      Q330P7
      Related
      ENSMUSP00000064437.9, ENSMUST00000069385.15
      Conserved Domains (1) summary
      pfam04440
      Location:1280
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164309073..164335243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499895.3XP_006499958.1  dysbindin domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006499958.1

      UniProtKB/Swiss-Prot
      Q9CRD4
      UniProtKB/TrEMBL
      Q330P7
      Conserved Domains (1) summary
      pfam04440
      Location:1280
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
    2. XM_030251864.2XP_030107724.1  dysbindin domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9CRD4
      UniProtKB/TrEMBL
      Q330P7
      Conserved Domains (1) summary
      pfam04440
      Location:1280
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)