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    Rnf115 ring finger protein 115 [ Mus musculus (house mouse) ]

    Gene ID: 67845, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf115provided by MGI
    Official Full Name
    ring finger protein 115provided by MGI
    Primary source
    MGI:MGI:1915095
    See related
    Ensembl:ENSMUSG00000028098 AllianceGenome:MGI:1915095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp364; 2610028E05Rik
    Summary
    Enables ubiquitin protein ligase activity. Involved in protein K48-linked ubiquitination and protein K63-linked ubiquitination. Located in cytosol. Is expressed in central nervous system and genitourinary system. Orthologous to human RNF115 (ring finger protein 115). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 14.4), CNS E14 (RPKM 14.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf115 in Genome Data Viewer
    Location:
    3 F2.1; 3 41.96 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96634869..96698471)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96727597..96791155)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene nudix hydrolase 17 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide C Neighboring gene STARR-positive B cell enhancer ABC_E6085 Neighboring gene predicted gene, 22581 Neighboring gene CD160 antigen Neighboring gene RIKEN cDNA 4930442L01 gene Neighboring gene PDZ domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response. Feng J, et al. Cell Death Dis, 2023 Dec 21. PMID 38129372, Free PMC Article
    2. The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection. Bilkei-Gorzo O, et al. EMBO J, 2022 Dec 1. PMID 36281581, Free PMC Article
    3. RNF115 deletion inhibits autophagosome maturation and growth of gastric cancer. Li R, et al. Cell Death Dis, 2020 Sep 26. PMID 32980859, Free PMC Article
    4. Rabring7, a novel Rab7 target protein with a RING finger motif. Mizuno K, et al. Mol Biol Cell, 2003 Sep. PMID 12972561, Free PMC Article
    5. RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA. Zhang ZD, et al. Nat Commun, 2020 Nov 2. PMID 33139700, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response.
      Title: RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response.
    2. The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection.
      Title: The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection.
    3. RNF115 deletion inhibits autophagosome maturation and growth of gastric cancer.
      Title: RNF115 deletion inhibits autophagosome maturation and growth of gastric cancer.
    4. RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA.
      Title: RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA.
    5. Rabring7 plays crucial roles as a Rab7 target protein in vesicle traffic to late endosome/lysosome and lysosome biogenesis (rabring7)
      Title: Rabring7, a novel Rab7 target protein with a RING finger motif.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF115
    Names
    RING-type E3 ubiquitin transferase RNF115
    Rab7-interacting RING finger protein
    Rabring7
    rabring 7
    zinc finger protein 364
    NP_080682.3
    XP_006502010.2
    XP_030108633.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026406.3 → NP_080682.3  E3 ubiquitin-protein ligase RNF115

      See identical proteins and their annotated locations for NP_080682.3

      Status: VALIDATED

      Source sequence(s)
      AC112261, AC127297
      Consensus CDS
      CCDS17647.1
      UniProtKB/Swiss-Prot
      Q8R5A1, Q9D0C1, Q9D885
      UniProtKB/TrEMBL
      Q3TWA8
      Related
      ENSMUSP00000029740.10, ENSMUST00000029740.14
      Conserved Domains (2) summary
      pfam13639
      Location:228 → 270
      zf-RING_2; Ring finger domain
      pfam14369
      Location:19 → 49
      zinc_ribbon_9; zinc-ribbon

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96634869..96698471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501947.5 → XP_006502010.2  E3 ubiquitin-protein ligase RNF115 isoform X1

      UniProtKB/TrEMBL
      Q3TWA8
      Conserved Domains (1) summary
      cd16800
      Location:188 → 234
      RING-H2_RNF115; RING finger, H2 subclass, found in RING finger protein 115 (RNF115) and similar proteins

    2. XM_030252773.1 → XP_030108633.1  E3 ubiquitin-protein ligase RNF115 isoform X2

      Conserved Domains (1) summary
      cd16800
      Location:146 → 192
      RING-H2_RNF115; RING finger, H2 subclass, found in RING finger protein 115 (RNF115) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0C1.1 GenPept UniProtKB/Swiss-Prot:Q9D0C1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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