Ctu1 cytosolic thiouridylase subunit 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctu1provided by MGI
Official Full Name: cytosolic thiouridylase subunit 1provided by MGI
Primary source: MGI:MGI:2385277
See related: Ensembl:ENSMUSG00000038888 AllianceGenome:MGI:2385277
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Atpbd3
Summary: Predicted to enable tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Located in mitochondrion. Is expressed in brain. Orthologous to human CTU1 (cytosolic thiouridylase subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 15.0), adrenal adult (RPKM 9.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.26 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43321400..43327724)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43671971..43678301)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein urmylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA thio-modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA wobble position uridine thiolation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA wobble uridine modification	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of cytosolic tRNA wobble base thiouridylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: cytoplasmic tRNA 2-thiolation protein 1

Names: ATP binding domain 3; ATP-binding domain-containing protein 3; cytoplasmic tRNA adenylyltransferase 1; cytosolic thiouridylase subunit 1 homolog

NP_663557.1

EC 2.7.7.-

XP_017177659.1

EC 2.7.7.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145582.1 → NP_663557.1 cytoplasmic tRNA 2-thiolation protein 1

See identical proteins and their annotated locations for NP_663557.1

Status: PROVISIONAL

Source sequence(s)

BC005752

Consensus CDS

CCDS21179.1

UniProtKB/Swiss-Prot

Q99J10

Related

ENSMUSP00000036770.9, ENSMUST00000038332.9

Conserved Domains (3) summary

TIGR00269
Location:207 → 308

TIGR00269; TIGR00269 family protein

COG0037
Location:54 → 329

TilS; tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]

cd01993
Location:54 → 243

Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

43321400..43327724

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017322170.3 → XP_017177659.1 cytoplasmic tRNA 2-thiolation protein 1 isoform X1

Conserved Domains (2) summary

cd01993
Location:54 → 243

Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

cl25646
Location:207 → 308

zn-ribbon_14; Zinc-ribbon