Cd300a CD300A molecule [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd300aprovided by MGI
Official Full Name: CD300A moleculeprovided by MGI
Primary source: MGI:MGI:2443411
See related: Ensembl:ENSMUSG00000034652 AllianceGenome:MGI:2443411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clm8; LMIR1; MMAC8; Pigr4; MAIR-1; MAIR-I; mcpir1; MAIR-Ia; B230315M08Rik
Summary: Enables phosphatase binding activity. Acts upstream of or within negative regulation of secretion by cell; receptor-mediated endocytosis; and serotonin secretion by mast cell. Located in plasma membrane. Is expressed in cerebral cortex ventricular layer; cortical plate; and testis. Orthologous to human CD300A (CD300a molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in spleen adult (RPKM 4.3), liver E18 (RPKM 1.5) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.54 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (114780006..114792772)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (114889152..114901946)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD300a Regulates Mouse Macrophage Functionality in Allergic Inflammation.
Title: CD300a Regulates Mouse Macrophage Functionality in Allergic Inflammation.
CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke.
Title: CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke.
Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a.
Title: Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a.
The inhibitory receptor CD300a is essential for neutrophil-mediated clearance of urinary tract infection in mice.
Title: The inhibitory receptor CD300a is essential for neutrophil-mediated clearance of urinary tract infection in mice.
CD300a contributes to the resolution of articular inflammation triggered by MSU crystals by controlling neutrophil apoptosis.
Title: CD300a contributes to the resolution of articular inflammation triggered by MSU crystals by controlling neutrophil apoptosis.
CD300 molecules participate in the mechanisms that viruses employ to develop immune evasion strategies and to infect host cells [Review].
Title: CD300 receptor family in viral infections.
CD300a seems to regulate the activity of various immune cells types involved in the process, including neutrophils, macrophages, and lymphocytes.
Title: The immunoreceptor CD300a controls the intensity of inflammation and dysfunction in a model of Ag-induced arthritis in mice.
these findings indicate a role for CD300a in allergic inflammation and its resolution
Title: Leukocyte CD300a Contributes to the Resolution of Murine Allergic Inflammation.
The results indicate that CD300a on MCs and DCs regulates neutrophil recruitment into the peritoneal cavity after cecal ligation and puncture (CLP).
Title: Immunoreceptor CD300a on mast cells and dendritic cells regulates neutrophil recruitment in a murine model of sepsis.
Epithelial apoptotic cells negatively regulated commensal-mediated signaling in dendritic cells via CD300a for Treg cell proliferation.
Title: Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylethanolamine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mast cell degranulation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NK T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of eosinophil activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of eosinophil migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mast cell degranulation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of serotonin secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of serotonin secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within serotonin secretion by mast cell	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CMRF35-like molecule 8

Names: CD300 antigen-like family member A; CD300A antigen; leukocyte mono-Ig-like receptor 1; mast cell-derived paired immunoglobulin-like receptor 1; myeloid-associated immunoglobulin-like receptor 1; polymeric immunoglobulin receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347654.2 → NP_001334583.1 CMRF35-like molecule 8 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AB091765, AK045869, AK053160, AL669969

Consensus CDS

CCDS83923.1

UniProtKB/Swiss-Prot

Q6SJQ0

Related

ENSMUSP00000036773.6, ENSMUST00000045151.6
NM_001359812.1 → NP_001346741.1 CMRF35-like molecule 8 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL669969

Conserved Domains (2) summary

cd05716
Location:64 → 153

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

pfam15330
Location:233 → 315

SIT; SHP2-interacting transmembrane adaptor protein, SIT
NM_170758.4 → NP_739564.1 CMRF35-like molecule 8 isoform 1 precursor

See identical proteins and their annotated locations for NP_739564.1

Status: VALIDATED

Source sequence(s)

AL669969

Consensus CDS

CCDS25613.1

UniProtKB/Swiss-Prot

B9EIB1, Q6SJQ0, Q7TN56, Q7TSN3, Q8CFN3

Related

ENSMUSP00000102192.3, ENSMUST00000106582.9

Conserved Domains (2) summary

cd05716
Location:33 → 122

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

pfam15330
Location:202 → 284

SIT; SHP2-interacting transmembrane adaptor protein, SIT

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

114780006..114792772

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245891.2 → XP_030101751.1 CMRF35-like molecule 8 isoform X1

UniProtKB/Swiss-Prot

B9EIB1, Q6SJQ0, Q7TN56, Q7TSN3, Q8CFN3

Conserved Domains (2) summary

cd05716
Location:33 → 122

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

pfam15330
Location:202 → 284

SIT; SHP2-interacting transmembrane adaptor protein, SIT