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    Slc25a36 solute carrier family 25, member 36 [ Mus musculus (house mouse) ]

    Gene ID: 192287, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25a36provided by MGI
    Official Full Name
    solute carrier family 25, member 36provided by MGI
    Primary source
    MGI:MGI:1924909
    See related
    Ensembl:ENSMUSG00000032449 AllianceGenome:MGI:1924909
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330005L02Rik
    Summary
    Predicted to enable pyrimidine nucleotide transmembrane transporter activity. Predicted to be involved in mitochondrial genome maintenance; pyrimidine nucleotide import into mitochondrion; and regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in embryo. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 8. Orthologous to human SLC25A36 (solute carrier family 25 member 36). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 20.5), CNS E18 (RPKM 14.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a36 in Genome Data Viewer
    Location:
    9 E3.3; 9 50.84 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96957014..96993094, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (97075281..97111041, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene casein kinase 1, alpha 1 pseudogene Neighboring gene predicted gene, 19325 Neighboring gene STARR-seq mESC enhancer starr_24985 Neighboring gene STARR-positive B cell enhancer ABC_E1392 Neighboring gene STARR-seq mESC enhancer starr_24987 Neighboring gene STARR-seq mESC enhancer starr_24989 Neighboring gene ribosomal protein L7A, pseudogene 10 Neighboring gene STARR-seq mESC enhancer starr_24990 Neighboring gene pyruvate kinase, muscle pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Slc25a36 modulates pluripotency of mouse embryonic stem cells by regulating mitochondrial function and glutathione level. Xin Y, et al. Biochem J, 2019 Jun 11. PMID 31036718
    2. Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. Hildyard JC, et al. Biochem J, 2003 Sep 15. PMID 12887330, Free PMC Article
    3. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
    4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    5. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables pyrimidine nucleotide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrimidine nucleotide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyrimidine nucleotide transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial genome maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial genome maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial genome maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pyrimidine nucleotide import into mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine nucleotide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine nucleotide transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 25 member 36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138756.4 → NP_620095.1  solute carrier family 25 member 36

      See identical proteins and their annotated locations for NP_620095.1

      Status: PROVISIONAL

      Source sequence(s)
      AC121121
      Consensus CDS
      CCDS23420.1
      UniProtKB/Swiss-Prot
      Q922G0
      Related
      ENSMUSP00000082302.5, ENSMUST00000085206.11
      Conserved Domains (2) summary
      PTZ00169
      Location:5 → 290
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:2 → 113
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      96957014..96993094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242678.4 → XP_011240980.1  solute carrier family 25 member 36 isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:156 → 245
      Mito_carr; Mitochondrial carrier protein

    2. XM_006510870.5 → XP_006510933.1  solute carrier family 25 member 36 isoform X1

      Conserved Domains (1) summary
      pfam00153
      Location:156 → 245
      Mito_carr; Mitochondrial carrier protein

    3. XM_006510871.3 → XP_006510934.1  solute carrier family 25 member 36 isoform X3

      Conserved Domains (1) summary
      pfam00153
      Location:54 → 150
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922G0.1 GenPept UniProtKB/Swiss-Prot:Q922G0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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