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    Zc3h11a zinc finger CCCH type containing 11A [ Mus musculus (house mouse) ]

    Gene ID: 70579, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zc3h11aprovided by MGI
    Official Full Name
    zinc finger CCCH type containing 11Aprovided by MGI
    Primary source
    MGI:MGI:1917829
    See related
    Ensembl:ENSMUSG00000102976 AllianceGenome:MGI:1917829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zc3hh11a; Zc3hdc11a; mKIAA0663; 1110003F06Rik; 5730454B08Rik; G630041M05Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be part of transcription export complex. Is expressed in 2-cell stage embryo; inner cell mass; and trophectoderm. Orthologous to several human genes including ZC3H11A (zinc finger CCCH-type containing 11A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 42.5), bladder adult (RPKM 39.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zc3h11a in Genome Data Viewer
    Location:
    1 E4; 1 57.94 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133547600..133589137, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133619862..133661399, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02294 Neighboring gene predicted gene, 23939 Neighboring gene small nuclear ribonucleoprotein E Neighboring gene predicted gene, 53475 Neighboring gene zinc finger, BED type containing 6 Neighboring gene STARR-seq mESC enhancer starr_02296 Neighboring gene STARR-seq mESC enhancer starr_02297 Neighboring gene STARR-seq mESC enhancer starr_02298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135586656-135586812 Neighboring gene STARR-seq mESC enhancer starr_02299 Neighboring gene lymphocyte transmembrane adaptor 1 Neighboring gene ATPase, Ca++ transporting, plasma membrane 4 Neighboring gene microRNA 6903

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes. Younis S, et al. Proc Natl Acad Sci U S A, 2023 Jun 6. PMID 37252988, Free PMC Article
    2. The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts. Kases K, et al. J Biol Chem, 2023 Aug. PMID 37356722, Free PMC Article
    3. Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment. Bhattacharjee R, et al. Nat Commun, 2024 Feb 8. PMID 38331934, Free PMC Article
    4. The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration. Slabber CF, et al. Sci Signal, 2023 May 30. PMID 37253089
    5. Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. Shu H, et al. Mol Cell Proteomics, 2004 Mar. PMID 14729942

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts.
      Title: The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts.
    2. Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes.
      Title: Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0663

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription export complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 11A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276767.1 → NP_001263696.1  zinc finger CCCH domain-containing protein 11A

      See identical proteins and their annotated locations for NP_001263696.1

      Status: VALIDATED

      Source sequence(s)
      AC124338
      Consensus CDS
      CCDS15297.1
      UniProtKB/Swiss-Prot
      Q6NXW9, Q6NZF1, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6
      UniProtKB/TrEMBL
      Q3TIV2, Q3UL31
      Related
      ENSMUSP00000141255.2, ENSMUST00000191896.6
      Conserved Domains (1) summary
      pfam15663
      Location:1 → 110
      zf-CCCH_3; Zinc-finger containing family

    2. NM_001357228.1 → NP_001344157.1  zinc finger CCCH domain-containing protein 11A

      Status: VALIDATED

      Source sequence(s)
      AC124338
      Consensus CDS
      CCDS15297.1
      UniProtKB/Swiss-Prot
      Q6NXW9, Q6NZF1, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6
      UniProtKB/TrEMBL
      Q3TIV2, Q3UL31
      Conserved Domains (1) summary
      pfam15663
      Location:1 → 110
      zf-CCCH_3; Zinc-finger containing family

    3. NM_144530.6 → NP_653113.4  zinc finger CCCH domain-containing protein 11A

      See identical proteins and their annotated locations for NP_653113.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124338
      Consensus CDS
      CCDS15297.1
      UniProtKB/Swiss-Prot
      Q6NXW9, Q6NZF1, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6
      UniProtKB/TrEMBL
      Q3TIV2, Q3UL31
      Conserved Domains (1) summary
      pfam15663
      Location:1 → 110
      zf-CCCH_3; Zinc-finger containing family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      133547600..133589137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NZF1.1 GenPept UniProtKB/Swiss-Prot:Q6NZF1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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