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    1700093K21Rik RIKEN cDNA 1700093K21 gene [ Mus musculus (house mouse) ]

    Gene ID: 67358, updated on 9-Dec-2024

    Summary

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    Official Symbol
    1700093K21Rikprovided by MGI
    Official Full Name
    RIKEN cDNA 1700093K21 geneprovided by MGI
    Primary source
    MGI:MGI:1914608
    See related
    Ensembl:ENSMUSG00000020286 AllianceGenome:MGI:1914608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b2b3025Clo
    Summary
    Predicted to be located in membrane. Used to study visceral heterotaxy. Orthologous to human C2orf74 (chromosome 2 open reading frame 74). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 25.5) See more
    Orthologs
    human all
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    Genomic context

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    See 1700093K21Rik in Genome Data Viewer
    Location:
    11 A3.2; 11 14.32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23466203..23471915, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23516202..23521319, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 34 Neighboring gene RIKEN cDNA 1700030C12 gene Neighboring gene STARR-positive B cell enhancer ABC_E9818 Neighboring gene predicted gene, 22753 Neighboring gene STARR-seq mESC enhancer starr_28912 Neighboring gene STARR-seq mESC enhancer starr_28914 Neighboring gene STARR-seq mESC enhancer starr_28915 Neighboring gene AHA1, activator of heat shock protein ATPase 2 Neighboring gene STARR-seq mESC enhancer starr_28916 Neighboring gene STARR-seq mESC enhancer starr_28917 Neighboring gene selenoprotein K, pseudogene 1 Neighboring gene SANT and BTB domain regulator of CSR

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The uncharacterized gene 1700093K21Rik and flanking regions are correlated with reproductive isolation in the house mouse, Mus musculus. Kass DH, et al. Mamm Genome, 2014 Jun. PMID 24549580
    2. Identification and integrative analysis of 28 novel genes specifically expressed and developmentally regulated in murine spermatogenic cells. Hong S, et al. J Biol Chem, 2005 Mar 4. PMID 15613475
    3. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    4. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The 1700093K21Rik gene and flanking regions are correlated with reproductive isolation in the house mouse.
      Title: The uncharacterized gene 1700093K21Rik and flanking regions are correlated with reproductive isolation in the house mouse, Mus musculus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein C2orf74 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110133.2 → NP_001103603.2  uncharacterized protein C2orf74 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 5' terminal non-coding exon compared to transcript variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL672049
      UniProtKB/TrEMBL
      A0A6Q6PKH4
      Related
      ENSMUSP00000131204.2, ENSMUST00000169264.8
      Conserved Domains (1) summary
      pfam15484
      Location:32 → 178
      DUF4642; Domain of unknown function (DUF4642)

    2. NM_001370913.1 → NP_001357842.1  uncharacterized protein C2orf74 homolog

      Status: VALIDATED

      Source sequence(s)
      AL672049
      UniProtKB/TrEMBL
      A0A6Q6PKH4
      Conserved Domains (1) summary
      pfam15484
      Location:32 → 178
      DUF4642; Domain of unknown function (DUF4642)

    3. NM_026105.5 → NP_080381.3  uncharacterized protein C2orf74 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the more predominant transcript variant. All three variants encode the same protein.
      Source sequence(s)
      AL672049
      UniProtKB/TrEMBL
      A0A6Q6PKH4
      Related
      ENSMUSP00000020527.7, ENSMUST00000020527.13
      Conserved Domains (1) summary
      pfam15484
      Location:32 → 178
      DUF4642; Domain of unknown function (DUF4642)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      23466203..23471915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514790.4 → XP_006514853.1  uncharacterized protein C2orf74 homolog isoform X1

      See identical proteins and their annotated locations for XP_006514853.1

      UniProtKB/Swiss-Prot
      Q810S2, Q9D9C4, Q9D9E2
      Conserved Domains (1) summary
      pfam15484
      Location:50 → 196
      DUF4642; Domain of unknown function (DUF4642)

    2. XM_006514789.3 → XP_006514852.1  uncharacterized protein C2orf74 homolog isoform X1

      See identical proteins and their annotated locations for XP_006514852.1

      UniProtKB/Swiss-Prot
      Q810S2, Q9D9C4, Q9D9E2
      Conserved Domains (1) summary
      pfam15484
      Location:50 → 196
      DUF4642; Domain of unknown function (DUF4642)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810S2.1 GenPept UniProtKB/Swiss-Prot:Q810S2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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