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    Dcakd dephospho-CoA kinase domain containing [ Mus musculus (house mouse) ]

    Gene ID: 68087, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dcakdprovided by MGI
    Official Full Name
    dephospho-CoA kinase domain containingprovided by MGI
    Primary source
    MGI:MGI:1915337
    See related
    Ensembl:ENSMUSG00000020935 AllianceGenome:MGI:1915337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3010024O21Rik; 6720485C15Rik
    Summary
    Predicted to enable dephospho-CoA kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Located in mitochondrion. Is expressed in ductus deferens and testis. Orthologous to human DCAKD (dephospho-CoA kinase domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 63.5), whole brain E14.5 (RPKM 59.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dcakd in Genome Data Viewer
    Location:
    11 E1; 11 66.71 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102884873..102919107, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102994047..103028370, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene complement component 1, q subcomponent-like 1 Neighboring gene RIKEN cDNA 2410004I01 gene Neighboring gene predicted gene, 34620 Neighboring gene STARR-seq mESC enhancer starr_30823 Neighboring gene microRNA 6931 Neighboring gene STARR-positive B cell enhancer ABC_E8458 Neighboring gene STARR-positive B cell enhancer ABC_E7071 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102889625-102889808 Neighboring gene STARR-seq mESC enhancer starr_30825 Neighboring gene N-myristoyltransferase 1 Neighboring gene predicted gene, 42090 Neighboring gene phospholipase C, delta 3 Neighboring gene STARR-seq mESC enhancer starr_30831

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
    2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    3. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22955

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dephospho-CoA kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dephospho-CoA kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dephospho-CoA kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    dephospho-CoA kinase domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417999.1 → NP_001404928.1  dephospho-CoA kinase domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      AL731670, AL731805
      UniProtKB/Swiss-Prot
      Q8BHC4

    2. NM_026551.4 → NP_080827.2  dephospho-CoA kinase domain-containing protein

      See identical proteins and their annotated locations for NP_080827.2

      Status: VALIDATED

      Source sequence(s)
      AL731670
      Consensus CDS
      CCDS25510.1
      UniProtKB/Swiss-Prot
      Q8BHC4
      Related
      ENSMUSP00000021313.3, ENSMUST00000021313.9
      Conserved Domains (1) summary
      PRK00081
      Location:1 → 196
      coaE; dephospho-CoA kinase; Reviewed

    RNA

    1. NR_184666.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL731670, AL731805

    2. NR_184667.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL731670, AL731805

    3. NR_184668.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL731670, AL731805

    4. NR_184669.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL731670, AL731805

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102884873..102919107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHC4.1 GenPept UniProtKB/Swiss-Prot:Q8BHC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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