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    Ecm1 extracellular matrix protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 13601, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ecm1provided by MGI
    Official Full Name
    extracellular matrix protein 1provided by MGI
    Primary source
    MGI:MGI:103060
    See related
    Ensembl:ENSMUSG00000028108 AllianceGenome:MGI:103060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p85
    Summary
    Enables interleukin-2 receptor binding activity. Acts upstream of or within several processes, including regulation of bone mineralization; regulation of type 2 immune response; and skeletal system development. Located in extracellular space. Is expressed in several structures, including alimentary system; autopod; bone; cardiovascular system; and skin. Human ortholog(s) of this gene implicated in lipoid proteinosis. Orthologous to human ECM1 (extracellular matrix protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 290.2), bladder adult (RPKM 142.1) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ecm1 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.91 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95641459..95646880, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95734147..95739876, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated Mcl1 enhancer cluster Neighboring gene endosulfine alpha Neighboring gene STARR-seq mESC enhancer starr_08389 Neighboring gene STARR-seq mESC enhancer starr_08391 Neighboring gene STARR-seq mESC enhancer starr_08393 Neighboring gene myeloid cell leukemia sequence 1 Neighboring gene ADAMTS-like 4 Neighboring gene STARR-seq mESC enhancer starr_08394 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95511513-95511622 Neighboring gene microRNA 7014 Neighboring gene STARR-positive B cell enhancer ABC_E2087 Neighboring gene threonyl-tRNA synthetase 2, mitochondrial (putative) Neighboring gene regulation of nuclear pre-mRNA domain containing 2 Neighboring gene predicted gene, 26361

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables interleukin-2 receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chondrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endochondral bone growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of T cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of bone mineralization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of type 2 immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    extracellular matrix protein 1
    Names
    secretory component p85

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252653.4NP_001239582.1  extracellular matrix protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      Consensus CDS
      CCDS57237.1
      UniProtKB/TrEMBL
      F8WI14, Q3TXB7
      Related
      ENSMUSP00000029753.7, ENSMUST00000029753.14
      Conserved Domains (1) summary
      pfam05782
      Location:21558
      ECM1; Extracellular matrix protein 1 (ECM1)
    2. NM_001355070.3NP_001341999.1  extracellular matrix protein 1 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      B7ZNR0
      Conserved Domains (1) summary
      pfam05782
      Location:21558
      ECM1; Extracellular matrix protein 1 (ECM1)
    3. NM_001409917.1NP_001396846.1  extracellular matrix protein 1 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TDX7
    4. NM_001409919.1NP_001396848.1  extracellular matrix protein 1 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      B7ZNR0
    5. NM_001409920.1NP_001396849.1  extracellular matrix protein 1 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    6. NM_001409921.1NP_001396850.1  extracellular matrix protein 1 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    7. NM_001409922.1NP_001396851.1  extracellular matrix protein 1 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TDX7
    8. NM_001409923.1NP_001396852.1  extracellular matrix protein 1 isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    9. NM_001409924.1NP_001396853.1  extracellular matrix protein 1 isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      B7ZNR0
    10. NM_001409925.1NP_001396854.1  extracellular matrix protein 1 isoform 11 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    11. NM_001409926.1NP_001396855.1  extracellular matrix protein 1 isoform 12 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    12. NM_001409927.1NP_001396856.1  extracellular matrix protein 1 isoform 13 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    13. NM_001409928.1NP_001396857.1  extracellular matrix protein 1 isoform 14 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    14. NM_001409929.1NP_001396858.1  extracellular matrix protein 1 isoform 15 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TDX7
    15. NM_001409930.1NP_001396859.1  extracellular matrix protein 1 isoform 16 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      B7ZNR0
    16. NM_001409931.1NP_001396860.1  extracellular matrix protein 1 isoform 17 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    17. NM_001409932.1NP_001396861.1  extracellular matrix protein 1 isoform 18 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      B7ZNR0, Q3TXB7
    18. NM_001409933.1NP_001396862.1  extracellular matrix protein 1 isoform 19 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TDX7
    19. NM_001409935.1NP_001396864.1  extracellular matrix protein 1 isoform 20 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      B7ZNR0
    20. NM_001409936.1NP_001396865.1  extracellular matrix protein 1 isoform 21 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      B7ZNR0
    21. NM_001409938.1NP_001396867.1  extracellular matrix protein 1 isoform 22 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    22. NM_001409939.1NP_001396868.1  extracellular matrix protein 1 isoform 23 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    23. NM_001409940.1NP_001396869.1  extracellular matrix protein 1 isoform 24 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TDX7
    24. NM_001409941.1NP_001396870.1  extracellular matrix protein 1 isoform 25 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      B7ZNR0
    25. NM_001409942.1NP_001396871.1  extracellular matrix protein 1 isoform 26 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    26. NM_001409943.1NP_001396872.1  extracellular matrix protein 1 isoform 27 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    27. NM_001409944.1NP_001396873.1  extracellular matrix protein 1 isoform 28 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q3TXB7
    28. NM_001409945.1NP_001396874.1  extracellular matrix protein 1 isoform 29 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      B7ZNR0, Q3TXB7
    29. NM_001409946.1NP_001396875.1  extracellular matrix protein 1 isoform 30 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
    30. NM_001409947.1NP_001396876.1  extracellular matrix protein 1 isoform 31 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      A0A8T9ITP3, Q9Z2R8
    31. NM_001409948.1NP_001396877.1  extracellular matrix protein 1 isoform 32 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      A0A8T9ITP3, Q9Z2R8
    32. NM_001409949.1NP_001396878.1  extracellular matrix protein 1 isoform 33 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      A0A8T9ITP3, Q9Z2R8
    33. NM_001409950.1NP_001396879.1  extracellular matrix protein 1 isoform 34 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      A0A8T9ITP3, Q9Z2R8
    34. NM_001409951.1NP_001396880.1  extracellular matrix protein 1 isoform 35 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      A0A8T9ITP3, Q9Z2R8
    35. NM_001409952.1NP_001396881.1  extracellular matrix protein 1 isoform 36 precursor

      Status: VALIDATED

      Source sequence(s)
      MG954306
      UniProtKB/TrEMBL
      Q9Z2R8
    36. NM_007899.5NP_031925.2  extracellular matrix protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_031925.2

      Status: VALIDATED

      Source sequence(s)
      MG954306
      Consensus CDS
      CCDS17619.1
      UniProtKB/Swiss-Prot
      Q3U5Q5, Q61508
      UniProtKB/TrEMBL
      Q3TDX7
      Related
      ENSMUSP00000112665.3, ENSMUST00000117507.10
      Conserved Domains (1) summary
      pfam05782
      Location:21559
      ECM1; Extracellular matrix protein 1 (ECM1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95641459..95646880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319450.3XP_017174939.1  extracellular matrix protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8T9ITP3, Q9Z2R8
      Conserved Domains (1) summary
      pfam05782
      Location:21452
      ECM1; Extracellular matrix protein 1 (ECM1)
    2. XM_011240008.4XP_011238310.1  extracellular matrix protein 1 isoform X2

      UniProtKB/TrEMBL
      Q3TXB7
      Conserved Domains (1) summary
      pfam05782
      Location:21576
      ECM1; Extracellular matrix protein 1 (ECM1)