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    Zfp646 zinc finger protein 646 [ Mus musculus (house mouse) ]

    Gene ID: 233905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp646provided by MGI
    Official Full Name
    zinc finger protein 646provided by MGI
    Primary source
    MGI:MGI:3665412
    See related
    Ensembl:ENSMUSG00000049739 AllianceGenome:MGI:3665412
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6820429M01
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZNF646 (zinc finger protein 646). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.7), thymus adult (RPKM 14.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp646 in Genome Data Viewer
    Location:
    7 F3; 7 69.8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127476081..127485168)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127876914..127885996)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3755 Neighboring gene syntaxin 4A (placental) Neighboring gene STARR-seq mESC enhancer starr_20194 Neighboring gene zinc finger protein 668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135020325-135020434 Neighboring gene serine protease 53 Neighboring gene vitamin K epoxide reductase complex, subunit 1 Neighboring gene branched chain ketoacid dehydrogenase kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 646

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404058.1 → NP_001390987.1  zinc finger protein 646

      Status: VALIDATED

      Source sequence(s)
      AC149222
      UniProtKB/Swiss-Prot
      Q6NV66
      UniProtKB/TrEMBL
      A0A0U1RNR6

    2. NM_001404059.1 → NP_001390988.1  zinc finger protein 646

      Status: VALIDATED

      Source sequence(s)
      AC149222
      UniProtKB/Swiss-Prot
      Q6NV66
      UniProtKB/TrEMBL
      A0A0U1RNR6

    3. NM_001404060.1 → NP_001390989.1  zinc finger protein 646

      Status: VALIDATED

      Source sequence(s)
      AC149222
      UniProtKB/Swiss-Prot
      Q6NV66
      UniProtKB/TrEMBL
      A0A0U1RNR6

    4. NM_001404061.1 → NP_001390990.1  zinc finger protein 646

      Status: VALIDATED

      Source sequence(s)
      AC149222
      UniProtKB/Swiss-Prot
      Q6NV66
      UniProtKB/TrEMBL
      A0A0U1RNR6

    5. NM_001404062.1 → NP_001390991.1  zinc finger protein 646

      Status: VALIDATED

      Source sequence(s)
      AC149222
      UniProtKB/Swiss-Prot
      Q6NV66
      UniProtKB/TrEMBL
      A0A0U1RNR6

    6. NM_172749.4 → NP_766337.2  zinc finger protein 646

      See identical proteins and their annotated locations for NP_766337.2

      Status: VALIDATED

      Source sequence(s)
      BC068300, BC079907
      Consensus CDS
      CCDS21882.1
      UniProtKB/Swiss-Prot
      Q6NV66
      UniProtKB/TrEMBL
      A0A0U1RNR6
      Related
      ENSMUSP00000052641.8, ENSMUST00000050383.8
      Conserved Domains (2) summary
      sd00017
      Location:1172 → 1192
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1681 → 1706
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127476081..127485168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NV66.1 GenPept UniProtKB/Swiss-Prot:Q6NV66

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