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    Usp16 ubiquitin specific peptidase 16 [ Mus musculus (house mouse) ]

    Gene ID: 74112, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp16provided by MGI
    Official Full Name
    ubiquitin specific peptidase 16provided by MGI
    Primary source
    MGI:MGI:1921362
    See related
    Ensembl:ENSMUSG00000025616 AllianceGenome:MGI:1921362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBPM; 1200004E02Rik; 2810483I07Rik; 6330514E22Rik
    Summary
    Enables histone H2A deubiquitinase activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; nervous system; and sensory organ. Orthologous to human USP16 (ubiquitin specific peptidase 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 10.7), CNS E11.5 (RPKM 8.0) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Usp16 in Genome Data Viewer
    Location:
    16 C3.3; 16 49.54 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (87251833..87280403)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (87454985..87483515)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene listerin E3 ubiquitin protein ligase 1 Neighboring gene predicted gene, 25896 Neighboring gene STARR-positive B cell enhancer ABC_E1186 Neighboring gene STARR-positive B cell enhancer ABC_E11624 Neighboring gene RWD domain containing 2B Neighboring gene STARR-positive B cell enhancer ABC_E10922 Neighboring gene RIKEN cDNA B130034C11 gene Neighboring gene STARR-positive B cell enhancer ABC_E5556 Neighboring gene chaperonin containing TCP1 subunit 8 Neighboring gene predicted gene, 24891

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation
    • Transgenic (1) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type endopeptidase activity  
    enables histone H2A deubiquitinase activity PubMed 
    enables histone H2A deubiquitinase activity  
    enables histone H2A deubiquitinase activity  
    enables histone binding  
    enables histone binding  
    enables protein binding PubMed 
    enables ribosomal small subunit binding  
    enables ribosomal small subunit binding  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables ubiquitin binding  
    enables ubiquitin binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in cell division  
    involved_in chromatin remodeling  
    involved_in mitotic nuclear division  
    involved_in monoubiquitinated protein deubiquitination  
    involved_in monoubiquitinated protein deubiquitination  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of ribosome biogenesis  
    involved_in positive regulation of ribosome biogenesis  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of translational elongation  
    involved_in positive regulation of translational elongation  
    involved_in protein homotetramerization  
    involved_in protein homotetramerization  
    involved_in proteolysis  
    involved_in regulation of cell cycle  
    involved_in regulation of transcription by RNA polymerase II PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 16
    Names
    deubiquitinating enzyme 16
    ubiquitin specific protease 16
    ubiquitin thioesterase 16
    ubiquitin thiolesterase 16
    ubiquitin-specific-processing protease 16
    NP_077220.2
    XP_006523163.1
    XP_006523164.1
    XP_006523165.1
    XP_036016050.1
    XP_036016051.1
    XP_036016052.1
    XP_036016053.1
    XP_036016054.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024258.2NP_077220.2  ubiquitin carboxyl-terminal hydrolase 16

      See identical proteins and their annotated locations for NP_077220.2

      Status: VALIDATED

      Source sequence(s)
      AC154631, AK160038, BE853521
      Consensus CDS
      CCDS28291.1
      UniProtKB/Swiss-Prot
      G5E860, Q99KM0, Q99LG0
      UniProtKB/TrEMBL
      D3YVU1
      Related
      ENSMUSP00000026710.6, ENSMUST00000026710.12
      Conserved Domains (3) summary
      COG5560
      Location:135823
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02667
      Location:624822
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:48122
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      87251833..87280403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523101.3XP_006523164.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X2

      UniProtKB/TrEMBL
      D3YVU1
      Related
      ENSMUSP00000114058.2, ENSMUST00000119504.8
      Conserved Domains (3) summary
      COG5207
      Location:3357
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02667
      Location:623821
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:48122
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    2. XM_006523102.5XP_006523165.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X3

      Conserved Domains (2) summary
      COG5560
      Location:25514
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02667
      Location:315513
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    3. XM_036160159.1XP_036016052.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X4

      Conserved Domains (2) summary
      cd02667
      Location:258456
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:135
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    4. XM_036160158.1XP_036016051.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X3

      Conserved Domains (2) summary
      COG5560
      Location:25514
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02667
      Location:315513
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    5. XM_036160160.1XP_036016053.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X4

      Conserved Domains (2) summary
      cd02667
      Location:258456
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:135
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    6. XM_006523100.3XP_006523163.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X1

      See identical proteins and their annotated locations for XP_006523163.1

      UniProtKB/Swiss-Prot
      G5E860, Q99KM0, Q99LG0
      UniProtKB/TrEMBL
      D3YVU1
      Conserved Domains (3) summary
      COG5560
      Location:135823
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02667
      Location:624822
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:48122
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    7. XM_036160161.1XP_036016054.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X4

      Conserved Domains (2) summary
      cd02667
      Location:258456
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:135
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    8. XM_036160157.1XP_036016050.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X3

      Conserved Domains (2) summary
      COG5560
      Location:25514
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02667
      Location:315513
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    RNA

    1. XR_004939251.1 RNA Sequence

      Related
      ENSMUST00000144759.8
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