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    Adam9 ADAM metallopeptidase domain 9 [ Mus musculus (house mouse) ]

    Gene ID: 11502, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adam9provided by MGI
    Official Full Name
    ADAM metallopeptidase domain 9provided by MGI
    Primary source
    MGI:MGI:105376
    See related
    Ensembl:ENSMUSG00000031555 AllianceGenome:MGI:105376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MDC9; Mltng; mKIAA0021
    Summary
    Enables SH3 domain binding activity; metalloendopeptidase activity; and protein kinase C binding activity. Involved in several processes, including membrane protein ectodomain proteolysis; positive regulation of membrane protein ectodomain proteolysis; and transforming growth factor beta receptor signaling pathway. Located in cytoplasm; external side of plasma membrane; and extracellular space. Is expressed in foregut-midgut junction. Used to study cone-rod dystrophy 9. Human ortholog(s) of this gene implicated in cone-rod dystrophy 9. Orthologous to human ADAM9 (ADAM metallopeptidase domain 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 28.0), lung adult (RPKM 12.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Adam9 in Genome Data Viewer
    Location:
    8 A2; 8 13.7 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25439627..25507138, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (24949611..25017040, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20948 Neighboring gene a disintegrin and metallopeptidase domain 5 Neighboring gene a disintegrin and metallopeptidase domain 32 Neighboring gene STARR-seq mESC enhancer starr_20951 Neighboring gene STARR-seq mESC enhancer starr_20952 Neighboring gene STARR-positive B cell enhancer mm9_chr8:26127373-26127674 Neighboring gene TM2 domain containing 2 Neighboring gene HtrA serine peptidase 4 Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within membrane protein intracellular domain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucocorticoid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to manganese ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 9
    Names
    a disintegrin and metallopeptidase domain 9 (meltrin gamma)
    a disintegrin and metalloproteinase domain 9 (meltrin gamma)
    metalloprotease/disintegrin/cysteine-rich protein 9
    myeloma cell metalloproteinase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270996.1NP_001257925.1  disintegrin and metalloproteinase domain-containing protein 9 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC156553, AK155672, BC052710, BF466217
      Consensus CDS
      CCDS85516.1
      UniProtKB/TrEMBL
      A0A140LHU0, Q3UG15
      Related
      ENSMUSP00000146545.2, ENSMUST00000208247.3
      Conserved Domains (7) summary
      pfam01391
      Location:755810
      Collagen; Collagen triple helix repeat (20 copies)
      smart00608
      Location:500636
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:212404
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:423497
      Disintegrin; Disintegrin
      pfam01421
      Location:212406
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:55160
      Pep_M12B_propep; Reprolysin family propeptide
      pfam06346
      Location:747820
      Drf_FH1; Formin Homology Region 1
    2. NM_007404.2NP_031430.2  disintegrin and metalloproteinase domain-containing protein 9 isoform 2 precursor

      See identical proteins and their annotated locations for NP_031430.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK148174, AK155672, AK161778, BF466217, BY780211, CJ078757
      UniProtKB/Swiss-Prot
      E9QPP2, Q60618, Q61072, Q61853, Q80U94
      UniProtKB/TrEMBL
      Q3UG15
      Conserved Domains (6) summary
      smart00050
      Location:423498
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:500636
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:212406
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:44163
      Pep_M12B_propep; Reprolysin family propeptide
      pfam06346
      Location:747802
      Drf_FH1; Formin Homology Region 1
      pfam07974
      Location:650673
      EGF_2; EGF-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      25439627..25507138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508986.5XP_006509049.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X1

      UniProtKB/TrEMBL
      Q3UG15
      Conserved Domains (6) summary
      smart00608
      Location:500636
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:650673
      EGF_2; EGF-like domain
      pfam00200
      Location:423496
      Disintegrin
      pfam01421
      Location:212406
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:44163
      Pep_M12B_propep; Reprolysin family propeptide
      pfam06346
      Location:747811
      Drf_FH1; Formin Homology Region 1
    2. XM_036153724.1XP_036009617.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X2

      Conserved Domains (4) summary
      smart00050
      Location:197272
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:274410
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:1180
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam06346
      Location:521594
      Drf_FH1; Formin Homology Region 1