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    Cd96 CD96 antigen [ Mus musculus (house mouse) ]

    Gene ID: 84544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd96provided by MGI
    Official Full Name
    CD96 antigenprovided by MGI
    Primary source
    MGI:MGI:1934368
    See related
    Ensembl:ENSMUSG00000022657 AllianceGenome:MGI:1934368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tactile; 1700109I12Rik
    Summary
    Acts upstream of or within negative regulation of natural killer cell cytokine production; negative regulation of type II interferon production; and response to lipopolysaccharide. Predicted to be located in cytoplasm. Is expressed in several structures, including blood; central nervous system; ganglia; heart; and lung. Human ortholog(s) of this gene implicated in C syndrome. Orthologous to human CD96 (CD96 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 13.8), testis adult (RPKM 6.8) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cd96 in Genome Data Viewer
    Location:
    16 B5; 16 30.45 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45856015..45940611, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (46035652..46120248, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24754 Neighboring gene predicted gene, 31198 Neighboring gene zinc finger BED-type containing 2 Neighboring gene STARR-seq mESC enhancer starr_40924 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46104635-46104888 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46120234-46120417 Neighboring gene adenosylhomocysteinase like Neighboring gene predicted gene, 26297

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD96 functions as a co-stimulatory receptor to enhance CD8(+) T cell activation and effector responses. Chiang EY, et al. Eur J Immunol, 2020 Jun. PMID 32043568
    2. CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells. Stanko K, et al. Proc Natl Acad Sci U S A, 2018 Mar 27. PMID 29531070, Free PMC Article
    3. Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz trigonocephaly) syndrome. Kaname T, et al. Am J Hum Genet, 2007 Oct. PMID 17847009, Free PMC Article
    4. The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1. Seth S, et al. Biochem Biophys Res Commun, 2007 Dec 28. PMID 17971293
    5. BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer. Feng M, et al. Signal Transduct Target Ther, 2021 Aug 20. PMID 34417435, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer.
      Title: BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer.
    2. CD96 functions as a co-stimulatory receptor to enhance CD8(+) T cell activation and effector responses.
      Title: CD96 functions as a co-stimulatory receptor to enhance CD8(+) T cell activation and effector responses.
    3. Blockade of CD96 completely restored the expansion and inflammatory properties of CD96(high) Th9 cells
      Title: CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells.
    4. knock-out mice display hyperinflammatory responses to lipopolysaccharide and resistance to lung carcinogenesis
      Title: The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions.
    5. CD96-driven adhesion to CD155 may be crucial in developmental processes
      Title: CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains.
    6. These results suggest a function of the CD96/CD155-adhesion system in T cell biology.
      Title: The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of natural killer cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of natural killer cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-cell surface protein tactile
    Names
    T cell activation, increased late expression
    cell surface antigen CD96
    t cell-activated increased late expression protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032465.2 → NP_115854.2  T-cell surface protein tactile precursor

      See identical proteins and their annotated locations for NP_115854.2

      Status: VALIDATED

      Source sequence(s)
      AK040539, BC052865
      Consensus CDS
      CCDS37348.1
      UniProtKB/Swiss-Prot
      Q3U0X8, Q7TMW0, Q8C9U6, Q99M67
      Related
      ENSMUSP00000023336.10, ENSMUST00000023336.10
      Conserved Domains (1) summary
      cl11960
      Location:43 → 131
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      45856015..45940611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317168.2 → XP_017172657.1  T-cell surface protein tactile isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:111 → 188
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U0X8.1 GenPept UniProtKB/Swiss-Prot:Q3U0X8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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