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    Pex26 peroxisomal biogenesis factor 26 [ Mus musculus (house mouse) ]

    Gene ID: 74043, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pex26provided by MGI
    Official Full Name
    peroxisomal biogenesis factor 26provided by MGI
    Primary source
    MGI:MGI:1921293
    See related
    Ensembl:ENSMUSG00000067825 AllianceGenome:MGI:1921293
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4632428M11Rik
    Summary
    This gene is a member of the peroxin-26 family. The encoded protein is probably required for protein import into peroxisomes. It may anchor Pex1 and Pex6 to peroxisome membranes. Defects in a similar gene in human are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2015]
    Expression
    Ubiquitous expression in ovary adult (RPKM 8.2), kidney adult (RPKM 7.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pex26 in Genome Data Viewer
    Location:
    6 F1; 6 57.13 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (121160176..121175796)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (121183217..121198837)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 3 Neighboring gene multiple inositol polyphosphate histidine phosphatase 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3676 Neighboring gene predicted gene, 30842 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:121167996-121168280 Neighboring gene predicted gene, 38651 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:121176131-121176438 Neighboring gene tubulin, alpha 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes. Matsumoto N, et al. Nat Cell Biol, 2003 May. PMID 12717447
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-membrane adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-membrane adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into peroxisome matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into peroxisome matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into peroxisome matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein import into peroxisome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein to membrane docking ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein to membrane docking ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisome assembly protein 26
    Names
    peroxin-26
    peroxisome biogenesis factor 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304773.1 → NP_001291702.1  peroxisome assembly protein 26 isoform 2

      See identical proteins and their annotated locations for NP_001291702.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AC153584, AK014598, AK042663, AK087637
      Consensus CDS
      CCDS80603.1
      UniProtKB/Swiss-Prot
      Q8BGI5
      Related
      ENSMUSP00000113233.2, ENSMUST00000120066.8
      Conserved Domains (1) summary
      pfam07163
      Location:1 → 301
      Pex26; Pex26 protein

    2. NM_001304774.1 → NP_001291703.1  peroxisome assembly protein 26 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the central coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC153584, AK014598, AK087637, AK145961
      Consensus CDS
      CCDS80604.1
      UniProtKB/TrEMBL
      D3Z3F5
      Related
      ENSMUSP00000113981.2, ENSMUST00000118234.8
      Conserved Domains (1) summary
      pfam07163
      Location:1 → 123
      Pex26; Pex26 protein

    3. NM_028730.6 → NP_083006.1  peroxisome assembly protein 26 isoform 1

      See identical proteins and their annotated locations for NP_083006.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC153584, AK014598, AK087637, BC058694
      Consensus CDS
      CCDS20488.1
      UniProtKB/Swiss-Prot
      Q3UGH5, Q8BGI5, Q9D661
      Related
      ENSMUSP00000085921.4, ENSMUST00000088561.10
      Conserved Domains (1) summary
      pfam07163
      Location:1 → 302
      Pex26; Pex26 protein

    RNA

    1. NR_130903.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 3' exon structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK040411, AK087637

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      121160176..121175796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321782.2 → XP_017177271.1  peroxisome assembly protein 26 isoform X2

      UniProtKB/TrEMBL
      D3Z3F5
      Conserved Domains (1) summary
      pfam07163
      Location:1 → 123
      Pex26; Pex26 protein

    2. XM_036152361.1 → XP_036008254.1  peroxisome assembly protein 26 isoform X1

      Conserved Domains (1) summary
      pfam07163
      Location:1 → 211
      Pex26; Pex26 protein

    3. XM_006506703.5 → XP_006506766.1  peroxisome assembly protein 26 isoform X1

      Conserved Domains (1) summary
      pfam07163
      Location:1 → 211
      Pex26; Pex26 protein

    RNA

    1. XR_004933625.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGI5.2 GenPept UniProtKB/Swiss-Prot:Q8BGI5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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