Trap1a tumor rejection antigen P1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trap1aprovided by MGI
Official Full Name: tumor rejection antigen P1Aprovided by MGI
Primary source: MGI:MGI:98818
See related: Ensembl:ENSMUSG00000051257 AllianceGenome:MGI:98818
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tra-P1A
Summary: Predicted to be located in nucleus. Is expressed in embryo; embryo endoderm; future midbrain; and yolk sac. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward placenta adult (RPKM 180.1) See more
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Genomic context

Location:: X F1; X 61.35 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (138234432..138238918)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (139333683..139338169)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these data reveal that Trap1a is an X-linked regulator that affects the differentiation potential of progenitor cells into T cells through a Notch-independent mechanism and identify an important function for the Trap1a gene
Title: Trap1a is an X-linked and cell-intrinsic regulator of thymocyte development.
Since multiple lineages of tumor cells share the tumor antigen P1A, we adoptively transferred transgenic T cells specific for P1A into mice with established P1A-expressing tumors.
Title: Different lineages of P1A-expressing cancer cells use divergent modes of immune evasion for T-cell adoptive therapy.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trap1a (e-PCR), detects polymorphism
- UniSTS:144666

Trap1a (e-PCR), detects polymorphism
- UniSTS:516157

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor rejection antigen P815A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.