Gfap glial fibrillary acidic protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gfapprovided by MGI
Official Full Name: glial fibrillary acidic proteinprovided by MGI
Primary source: MGI:MGI:95697
See related: Ensembl:ENSMUSG00000020932 AllianceGenome:MGI:95697
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: A structural constituent of cytoskeleton. Involved in regulation of chaperone-mediated autophagy. Acts upstream of or within with a positive effect on D-aspartate import across plasma membrane; gene expression; and intracellular protein transport. Acts upstream of or within several processes, including long-term synaptic potentiation; neurogenesis; and positive regulation of Schwann cell proliferation. Located in several cellular components, including astrocyte end-foot; cell body; and intermediate filament. Is expressed in several structures, including alimentary system; hemolymphoid system; integumental system; nervous system; and sensory organ. Used to study Alexander disease. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 34.4), frontal lobe adult (RPKM 32.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 66.48 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (102778162..102791368, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (102887336..102897200, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Astrocyte S100beta expression and selective differentiation to GFAP and GS in the entorhinal cortex during ageing in the 3xTg-Alzheimer's disease mouse model.
Title: Astrocyte S100β expression and selective differentiation to GFAP and GS in the entorhinal cortex during ageing in the 3xTg-Alzheimer's disease mouse model.
Large-scale gene expression changes in APP/PSEN1 and GFAP mutation models exhibit high congruence with Alzheimer's disease.
Title: Large-scale gene expression changes in APP/PSEN1 and GFAP mutation models exhibit high congruence with Alzheimer's disease.
Fate Specification of GFAP-Negative Primitive Neural Stem Cells and Their Progeny at Clonal Resolution.
Title: Fate Specification of GFAP-Negative Primitive Neural Stem Cells and Their Progeny at Clonal Resolution.
STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease.
Title: STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease.
GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming.
Title: GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming.
Selective Depletion of Adult GFAP-Expressing Tanycytes Leads to Hypogonadotropic Hypogonadism in Males.
Title: Selective Depletion of Adult GFAP-Expressing Tanycytes Leads to Hypogonadotropic Hypogonadism in Males.
RNAi-mediated suppression of vimentin or glial fibrillary acidic protein prevents the establishment of Muller glial cell hypertrophy in progressive retinal degeneration.
Title: RNAi-mediated suppression of vimentin or glial fibrillary acidic protein prevents the establishment of Müller glial cell hypertrophy in progressive retinal degeneration.
Evaluation of Traumatic Spinal Cord Injury in a Rat Model Using (99m)Tc-GA-5 as a Potential In Vivo Tracer.
Title: Evaluation of Traumatic Spinal Cord Injury in a Rat Model Using (99m)Tc-GA-5 as a Potential In Vivo Tracer.
Folic acid ameliorates neonatal isolation-induced autistic like behaviors in rats: epigenetic modifications of BDNF and GFAP promotors.
Title: Folic acid ameliorates neonatal isolation-induced autistic like behaviors in rats: epigenetic modifications of BDNF and GFAP promotors.
Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury.
Title: Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gfap (e-PCR), detects polymorphism
- UniSTS:255288

Gfap (e-PCR), detects polymorphism
- UniSTS:143193

Gfap (e-PCR), detects polymorphism
- UniSTS:143194

Gfap (e-PCR), detects polymorphism
- UniSTS:143195

Gfap (e-PCR), detects polymorphism
- UniSTS:143196

BB310338 (e-PCR)
- UniSTS:208752

AI836096 (e-PCR)
- UniSTS:180336

K01347 (e-PCR)
- UniSTS:180338

Gfap (e-PCR), detects polymorphism
- UniSTS:531078

Gfap (e-PCR), detects polymorphism
- UniSTS:497295

Gfap (e-PCR), detects polymorphism
- UniSTS:499093

Gfap (e-PCR), detects polymorphism
- UniSTS:275866

PMC125376P2 (e-PCR)
- UniSTS:270497

NoName (e-PCR)
- UniSTS:489131

K01347 (e-PCR)
- UniSTS:124860

D11Nds7 (e-PCR), detects polymorphism
- UniSTS:141781

Gfap (e-PCR), detects polymorphism
- UniSTS:547817

Gfap (e-PCR), detects polymorphism
- UniSTS:265458

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect D-aspartate import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of Schwann cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within astrocyte development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intermediate filament organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intermediate filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intermediate filament-based process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of Schwann cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of chaperone-mediated autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of chaperone-mediated autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chaperone-mediated autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neurotransmitter uptake	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in astrocyte end-foot	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasmic side of lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	HDA more info	PubMed

General protein information

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Preferred Names: glial fibrillary acidic protein

Names: intermediate filament protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001131020.1 → NP_001124492.1 glial fibrillary acidic protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK140151, BC139357, BU700210

Consensus CDS

CCDS48950.1

UniProtKB/Swiss-Prot

P03995

Related

ENSMUSP00000077061.5, ENSMUST00000077902.5

Conserved Domains (2) summary

pfam00038
Location:65 → 373

Filament; Intermediate filament protein

pfam04732
Location:4 → 63

Filament_head; Intermediate filament head (DNA binding) region
NM_010277.3 → NP_034407.2 glial fibrillary acidic protein isoform 2

See identical proteins and their annotated locations for NP_034407.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct C-terminus when compared to isoform 1.

Source sequence(s)

AI835063, AK079577, BC139357, BE651678, CX223233

Consensus CDS

CCDS25507.1

UniProtKB/Swiss-Prot

A1E2H7, A2AH87, B2RTI7, P03995, Q09J71, Q3USS4, Q496R4, Q496S3, Q7TQ30, Q80VX6, Q925K2, Q925K3

Related

ENSMUSP00000064691.4, ENSMUST00000067444.10

Conserved Domains (2) summary

pfam00038
Location:65 → 373

Filament; Intermediate filament protein

pfam04732
Location:4 → 63

Filament_head; Intermediate filament head (DNA binding) region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

102778162..102791368 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245571.2 → XP_030101431.1 glial fibrillary acidic protein isoform X1

Conserved Domains (2) summary

pfam00038
Location:65 → 373

Filament; Intermediate filament protein

pfam04732
Location:4 → 63

Filament_head; Intermediate filament head (DNA binding) region