M6pr mannose-6-phosphate receptor, cation dependent [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: M6prprovided by MGI
Official Full Name: mannose-6-phosphate receptor, cation dependentprovided by MGI
Primary source: MGI:MGI:96904
See related: Ensembl:ENSMUSG00000007458 AllianceGenome:MGI:96904
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mpr46; CD-MPR
Summary: Predicted to enable retromer complex binding activity. Involved in lysosomal transport. Acts upstream of or within secretion of lysosomal enzymes. Located in late endosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and skin. Orthologous to human M6PR (mannose-6-phosphate receptor, cation dependent). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 50.8), bladder adult (RPKM 46.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 57.52 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (122285679..122294639)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (122308720..122317680)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Finally, Chlamydia trachomatis infection interferes with the SNX5:cation-independent mannose-6-phosphate receptor interaction, suggesting that Chlamydia IncE and cation-independent mannose-6-phosphate receptor are dependent on the same binding surface on SNX5.
Title: Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction.
We conclude that M6PR is an important receptor used by HIV-1 to cross the blood-brain barrier.
Title: Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier.
Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice
Title: Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice.
the alpha-galactosidase enzyme is incorporated via cation-independent mannose 6-phosphate receptors in Schwann cells
Title: Establishment of immortalized Schwann cells from Fabry mice and their low uptake of recombinant alpha-galactosidase.
epinephrine restores the M6P receptor-mediated functional transport of (131)I-P-beta-glucuronidase across the blood brain barrier in adults to levels seen in the neonate
Title: Epinephrine enhances lysosomal enzyme delivery across the blood brain barrier by up-regulation of the mannose 6-phosphate receptor.
Data characterize the retrograde transport of mannose 6-phosphate receptor MPR46 from endosomes to the trans-Golgi network by an in vitro transport assay using mouse fibroblast cell lines.
Title: Characterization of the in vitro retrograde transport of MPR46.
The murine 46-kDa mannose 6-phosphate receptor has the capacity to deliver its cargo proteins to lysosomes even in the absence of endosomal acidification.
Title: The 46-kDa mannose 6-phosphate receptor does not depend on endosomal acidification for delivery of hydrolases to lysosomes.
there is not a an Mpr300- or Mpr46-dependent pathway of granzyme-mediated killing in internalization of monomeric and complexed granzyme B
Title: Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.
Mannose 6-phosphate receptor has a role in acid sphingomyelinase deficiency
Title: Mannose 6-phosphate receptor-mediated uptake is defective in acid sphingomyelinase-deficient macrophages: implications for Niemann-Pick disease enzyme replacement therapy.
These results indicate that beta-glucuronidase transport into brain parenchyma in early postnatal life is mediated by the mannose 6-phosphate/insulin-like growth factor II receptor.
Title: Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables retromer complex binding	IEA Inferred from Electronic Annotation more info
enables retromer complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular protein transport	TAS Traceable Author Statement more info	PubMed
involved_in lysosomal transport	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting to lysosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to lysosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within secretion of lysosomal enzymes	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cation-dependent mannose-6-phosphate receptor

Names: 46 kDa mannose 6-phosphate receptor; CD Man-6-P receptor; MPR 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.