Stk38 serine/threonine kinase 38 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stk38provided by MGI
Official Full Name: serine/threonine kinase 38provided by MGI
Primary source: MGI:MGI:2442572
See related: Ensembl:ENSMUSG00000024006 AllianceGenome:MGI:2442572
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ndr1; 5830476G13Rik; 9530097A09Rik
Summary: Predicted to enable several functions, including ATP binding activity; UFM1-modified protein reader activity; and magnesium ion binding activity. Predicted to be involved in several processes, including DNA damage checkpoint signaling; negative regulation of MAP kinase activity; and protein phosphorylation. Predicted to be located in cytosol and nucleus. Predicted to be active in glutamatergic synapse and site of double-strand break. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and nose. Orthologous to human STK38 (serine/threonine kinase 38). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 16.0), thymus adult (RPKM 15.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.03 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (29189854..29226979, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (28970880..29008010, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation.
Title: Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation.
Molecular Mechanism of Biofilm Locator Protein Kinase Dbf2p-related kinase 1 in Regulating Innate Immune Response to Interleukin 17-induced Viral Pneumonia.
Title: Molecular Mechanism of Biofilm Locator Protein Kinase Dbf2p-related kinase 1 in Regulating Innate Immune Response to Interleukin 17-induced Viral Pneumonia.
These results revealed that Stk38 kinase catalyzes the phosphorylation of Rbm24 during sarcomerogensis and this orchestrates accurate sarcomere alignment.
Title: Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes.
a novel and intimate link between the protein kinase NDR1 and TGFbeta signaling
Title: Identification of a Novel Link between the Protein Kinase NDR1 and TGFβ Signaling in Epithelial Cells.
Stk38 protein kinase has a role in inhibiting TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages
Title: Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages.
Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling.
Title: MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.
reduction in the abundances of the NDR proteins NDR1 and NDR2 results in defective responses to proapoptotic stimuli, thereby facilitating the development of tumors
Title: Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124263 (e-PCR)
- UniSTS:161085

Stk38 (e-PCR), detects polymorphism
- UniSTS:527570

BB217838 (e-PCR)
- UniSTS:186095

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables UFM1-modified protein reader activity	ISO Inferred from Sequence Orthology more info
enables UFM1-modified protein reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone reader activity	ISO Inferred from Sequence Orthology more info
enables histone reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables mitogen-activated protein kinase kinase kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein kinase 38

Names: NDR1 protein kinase; nuclear Dbf2-related kinase 1

NP_001344102.1

EC 2.7.11.1

NP_598876.1

EC 2.7.11.1

XP_011244534.1

EC 2.7.11.1

XP_011244535.1

EC 2.7.11.1

XP_030105270.1

EC 2.7.11.1

XP_030105271.1

EC 2.7.11.1

XP_036016133.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357173.1 → NP_001344102.1 serine/threonine-protein kinase 38

Status: VALIDATED

Source sequence(s)

AY292399, BE686860, BY750361, CT025867, CX202466

Consensus CDS

CCDS28589.1

UniProtKB/Swiss-Prot

Q91VJ4

Related

ENSMUSP00000113657.2, ENSMUST00000119274.3

Conserved Domains (1) summary

cd05628
Location:87 → 462

STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1
NM_134115.3 → NP_598876.1 serine/threonine-protein kinase 38

See identical proteins and their annotated locations for NP_598876.1

Status: VALIDATED

Source sequence(s)

AC167363, BE686860, CT025867

Consensus CDS

CCDS28589.1

UniProtKB/Swiss-Prot

Q91VJ4

Related

ENSMUSP00000009138.6, ENSMUST00000009138.13

Conserved Domains (1) summary

cd05628
Location:87 → 462

STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

29189854..29226979 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249410.2 → XP_030105270.1 serine/threonine-protein kinase 38 isoform X3

UniProtKB/TrEMBL

A0A3B2W7L2

Conserved Domains (1) summary

cl21453
Location:1 → 289

PKc_like; Protein Kinases, catalytic domain
XM_030249411.1 → XP_030105271.1 serine/threonine-protein kinase 38 isoform X3

UniProtKB/TrEMBL

A0A3B2W7L2

Related

ENSMUSP00000156592.2, ENSMUST00000141431.8

Conserved Domains (1) summary

cl21453
Location:1 → 289

PKc_like; Protein Kinases, catalytic domain
XM_011246232.3 → XP_011244534.1 serine/threonine-protein kinase 38 isoform X2

See identical proteins and their annotated locations for XP_011244534.1

Conserved Domains (1) summary

cd05628
Location:36 → 411

STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1
XM_011246233.3 → XP_011244535.1 serine/threonine-protein kinase 38 isoform X2

See identical proteins and their annotated locations for XP_011244535.1

Conserved Domains (1) summary

cd05628
Location:36 → 411

STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1
XM_036160240.1 → XP_036016133.1 serine/threonine-protein kinase 38 isoform X1

UniProtKB/Swiss-Prot

Q91VJ4

Related

ENSMUSP00000156711.2, ENSMUST00000232836.2

Conserved Domains (1) summary

cd05628
Location:87 → 462

STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1