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    Vwc2l von Willebrand factor C domain-containing protein 2-like [ Mus musculus (house mouse) ]

    Gene ID: 320460, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Vwc2lprovided by MGI
    Official Full Name
    von Willebrand factor C domain-containing protein 2-likeprovided by MGI
    Primary source
    MGI:MGI:2444069
    See related
    Ensembl:ENSMUSG00000045648 AllianceGenome:MGI:2444069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brl; A830006F12Rik
    Summary
    Acts upstream of or within negative regulation of BMP signaling pathway and positive regulation of neuron differentiation. Located in extracellular space. Part of AMPA glutamate receptor complex. Is expressed in several structures, including central nervous system; gut; hemolymphoid system gland; liver; and lung. Orthologous to human VWC2L (von Willebrand factor C domain containing 2 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Vwc2l in Genome Data Viewer
    Location:
    1 C3; 1 35.46 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (70764471..70928097)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (70725439..70888938)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 16 Neighboring gene STARR-seq mESC enhancer starr_01229 Neighboring gene predicted gene, 23422 Neighboring gene predicted gene, 57571 Neighboring gene STARR-seq mESC enhancer starr_01230 Neighboring gene predicted gene, 29906 Neighboring gene predicted gene, 57799 Neighboring gene STARR-positive B cell enhancer ABC_E5769 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01231 Neighboring gene predicted gene, 53490 Neighboring gene BRCA1 associated RING domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Modulation of matrix mineralization by Vwc2-like protein and its novel splicing isoforms. Ohyama Y, et al. Biochem Biophys Res Commun, 2012 Feb 3. PMID 22209847, Free PMC Article
    2. A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. Miwa H, et al. FEBS Lett, 2009 Nov 19. PMID 19852960
    3. Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons. Machado CB, et al. Development, 2014 Feb. PMID 24496616, Free PMC Article
    4. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Schwenk J, et al. Neuron, 2012 May 24. PMID 22632720
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    von Willebrand factor C domain-containing protein 2-like
    Names
    Brorin-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310658.2 → NP_001297587.1  von Willebrand factor C domain-containing protein 2-like isoform 2 precursor

      See identical proteins and their annotated locations for NP_001297587.1

      Status: VALIDATED

      Source sequence(s)
      AC129933, AC130481
      Consensus CDS
      CCDS78606.1
      UniProtKB/Swiss-Prot
      Q505H4
      Related
      ENSMUSP00000125014.2, ENSMUST00000161937.2

    2. NM_177164.4 → NP_796138.2  von Willebrand factor C domain-containing protein 2-like isoform 1 precursor

      See identical proteins and their annotated locations for NP_796138.2

      Status: VALIDATED

      Source sequence(s)
      AC129933, AC130481
      Consensus CDS
      CCDS15028.1
      UniProtKB/Swiss-Prot
      B7X8X0, E0CXU0, E6Y2G9, Q505H4, Q8BNE9, Q8BNU5
      Related
      ENSMUSP00000058142.6, ENSMUST00000053922.12
      Conserved Domains (1) summary
      cl17735
      Location:116 → 171
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      70764471..70928097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496064.4 → XP_006496127.1  von Willebrand factor C domain-containing protein 2-like isoform X2

      Conserved Domains (1) summary
      cl17735
      Location:116 → 171
      VWC; von Willebrand factor type C domain

    2. XM_006496063.5 → XP_006496126.1  von Willebrand factor C domain-containing protein 2-like isoform X1

      See identical proteins and their annotated locations for XP_006496126.1

      UniProtKB/Swiss-Prot
      B7X8X0, E0CXU0, E6Y2G9, Q505H4, Q8BNE9, Q8BNU5
      Conserved Domains (1) summary
      cl17735
      Location:116 → 171
      VWC; von Willebrand factor type C domain

    RNA

    1. XR_373257.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q505H4.1 GenPept UniProtKB/Swiss-Prot:Q505H4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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