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    TAF2 Taf2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TAF2
    Official Full Name
    Taf2p
    Primary source
    SGD:S000000638
    Locus tag
    YCR042C
    See related
    AllianceGenome:SGD:S000000638; FungiDB:YCR042C; VEuPathDB:YCR042C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TAF150; TSM1
    Summary
    Enables chromatin binding activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 40. Orthologous to human TAF2 (TATA-box binding protein associated factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TAF2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (201174..205397, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Ras family guanine nucleotide exchange factor BUD5 Neighboring gene homeodomain mating type protein alpha2 Neighboring gene transcriptional co-activator mating type protein alpha Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The TSM1 gene of Saccharomyces cerevisiae overlaps the MAT locus. Ray BL, et al. Curr Genet, 1991 Jul. PMID 1840512
    2. TAF25p, a non-histone-like subunit of TFIID and SAGA complexes, is essential for total mRNA gene transcription in vivo. Sanders SL, et al. J Biol Chem, 1999 Jul 2. PMID 10383379
    3. TAF-Containing and TAF-independent forms of transcriptionally active TBP in vivo. Kuras L, et al. Science, 2000 May 19. PMID 10818000
    4. The yeast GAL11 protein binds to the transcription factor IIE through GAL11 regions essential for its in vivo function. Sakurai H, et al. Proc Natl Acad Sci U S A, 1996 Sep 3. PMID 8790357, Free PMC Article
    5. Taf2 mediates DNA binding of Taf14. Klein BJ, et al. Nat Commun, 2022 Jun 8. PMID 35676274, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taf2 mediates DNA binding of Taf14.
      Title: Taf2 mediates DNA binding of Taf14.
    2. the mechanism through which Taf14 suppresses taf2(ts) alleles, shedding light on how Taf2-Taf14 interaction contributes to TFIID complex organization and identifying a potential role for Taf14 in mediating TFIID-chromatin interactions.
      Title: The C Terminus of the RNA Polymerase II Transcription Factor IID (TFIID) Subunit Taf2 Mediates Stable Association of Subunit Taf14 into the Yeast TFIID Complex.
    3. a specific effect of a Taf1 mutation on Taf2 occupancy that may reflect the spatial relationship between Taf1 and Taf2 within TFIID
      Title: Genome-wide localization analysis of a complete set of Tafs reveals a specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Taf2p
    NP_009971.1
    • TFIID subunit (150 kDa); involved in RNA polymerase II transcription initiation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      201174..205397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178756.1 → NP_009971.1  TPA: Taf2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009971.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR51, P23255
      UniProtKB/TrEMBL
      B5VEY4
      Conserved Domains (1) summary
      cd09839
      Location:30 → 674
      M1_like_TAF2; TATA binding protein (TBP) associated factor 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23255.3

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