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    Apoe apolipoprotein E [ Mus musculus (house mouse) ]

    Gene ID: 11816, updated on 28-Jan-2025

    Summary

    Official Symbol
    Apoeprovided by MGI
    Official Full Name
    apolipoprotein Eprovided by MGI
    Primary source
    MGI:MGI:88057
    See related
    Ensembl:ENSMUSG00000002985 AllianceGenome:MGI:88057
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apo-E
    Summary
    This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015]
    Expression
    Biased expression in liver adult (RPKM 9050.0), liver E18 (RPKM 4149.1) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Apoe in Genome Data Viewer
    Location:
    7 A3; 7 9.94 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19430169..19434326, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19696244..19701310, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein C2 like Neighboring gene apolipoprotein C-IV Neighboring gene STARR-seq mESC enhancer starr_18215 Neighboring gene apolipoprotein C-I Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene predicted gene, 38955 Neighboring gene nectin cell adhesion molecule 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 39
    Function Evidence Code Pubs
    enables amyloid-beta binding  
    enables amyloid-beta binding  
    enables antioxidant activity  
    enables antioxidant activity  
    enables cholesterol transfer activity  
    enables cholesterol transfer activity PubMed 
    enables enzyme binding  
    enables enzyme binding  
    enables heparan sulfate proteoglycan binding PubMed 
    enables heparan sulfate proteoglycan binding  
    enables heparin binding  
    enables heparin binding  
    enables hydroxyapatite binding  
    enables identical protein binding  
    enables identical protein binding  
    enables lipid binding  
    enables lipid transporter activity  
    enables lipoprotein particle binding PubMed 
    enables low-density lipoprotein particle receptor binding  
    enables low-density lipoprotein particle receptor binding  
    enables metal chelating activity  
    enables metal chelating activity  
    enables phosphatidylcholine-sterol O-acyltransferase activator activity  
    enables phosphatidylcholine-sterol O-acyltransferase activator activity PubMed 
    enables phosphatidylcholine-sterol O-acyltransferase activator activity  
    enables phospholipid binding  
    enables phospholipid binding  
    enables phospholipid binding  
    enables protein binding PubMed 
    enables protein dimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein-containing complex binding  
    enables receptor ligand activity  
    enables signaling receptor binding  
    enables tau protein binding  
    enables tau protein binding  
    enables very-low-density lipoprotein particle receptor binding  
    enables very-low-density lipoprotein particle receptor binding  
    Items 1 - 25 of 39
    Items 1 - 25 of 184
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect AMPA glutamate receptor clustering  
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within_positive_effect NMDA glutamate receptor clustering  
    involved_in acylglycerol homeostasis  
    involved_in amyloid precursor protein metabolic process  
    involved_in amyloid precursor protein metabolic process  
    acts_upstream_of_or_within artery morphogenesis PubMed 
    NOT acts_upstream_of_or_within axon regeneration PubMed 
    involved_in cellular oxidant detoxification  
    involved_in cellular response to lipoprotein particle stimulus  
    acts_upstream_of_or_within cholesterol catabolic process PubMed 
    involved_in cholesterol efflux  
    acts_upstream_of_or_within cholesterol efflux PubMed 
    acts_upstream_of_or_within cholesterol efflux PubMed 
    involved_in cholesterol efflux  
    acts_upstream_of_or_within cholesterol homeostasis PubMed 
    acts_upstream_of_or_within cholesterol homeostasis PubMed 
    involved_in cholesterol homeostasis PubMed 
    involved_in cholesterol homeostasis  
    involved_in cholesterol metabolic process  
    acts_upstream_of_or_within cholesterol metabolic process PubMed 
    involved_in cholesterol metabolic process  
    involved_in chylomicron remnant clearance  
    involved_in chylomicron remnant clearance  
    acts_upstream_of_or_within circulatory system development PubMed 
    involved_in fatty acid homeostasis  
    involved_in fatty acid homeostasis  
    acts_upstream_of_or_within_negative_effect gene expression PubMed 
    involved_in high-density lipoprotein particle assembly  
    involved_in high-density lipoprotein particle assembly  
    involved_in high-density lipoprotein particle clearance  
    involved_in high-density lipoprotein particle clearance  
    involved_in high-density lipoprotein particle remodeling  
    involved_in high-density lipoprotein particle remodeling  
    involved_in intermediate-density lipoprotein particle clearance  
    involved_in intermediate-density lipoprotein particle clearance  
    acts_upstream_of_or_within intracellular calcium ion homeostasis PubMed 
    acts_upstream_of_or_within lipid homeostasis PubMed 
    acts_upstream_of_or_within lipid metabolic process PubMed 
    involved_in lipid transport  
    involved_in lipid transport involved in lipid storage PubMed 
    acts_upstream_of_or_within lipoprotein biosynthetic process PubMed 
    involved_in lipoprotein biosynthetic process  
    involved_in lipoprotein biosynthetic process  
    acts_upstream_of_or_within lipoprotein catabolic process PubMed 
    acts_upstream_of_or_within lipoprotein metabolic process PubMed 
    acts_upstream_of_or_within lipoprotein metabolic process PubMed 
    involved_in lipoprotein metabolic process  
    involved_in locomotory exploration behavior  
    involved_in locomotory exploration behavior  
    involved_in long-chain fatty acid transport  
    involved_in long-chain fatty acid transport  
    involved_in long-term memory  
    involved_in long-term memory  
    involved_in low-density lipoprotein particle remodeling PubMed 
    acts_upstream_of_or_within maintenance of location in cell PubMed 
    involved_in melanosome organization PubMed 
    involved_in melanosome organization  
    involved_in negative regulation of MAP kinase activity  
    involved_in negative regulation of amyloid fibril formation PubMed 
    involved_in negative regulation of amyloid-beta formation  
    involved_in negative regulation of amyloid-beta formation  
    involved_in negative regulation of blood coagulation  
    involved_in negative regulation of blood vessel endothelial cell migration  
    involved_in negative regulation of blood vessel endothelial cell migration  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of cholesterol biosynthetic process  
    involved_in negative regulation of cholesterol biosynthetic process  
    involved_in negative regulation of cholesterol efflux  
    acts_upstream_of_or_within negative regulation of dendritic spine development  
    acts_upstream_of_or_within negative regulation of dendritic spine maintenance  
    involved_in negative regulation of endothelial cell migration  
    involved_in negative regulation of endothelial cell proliferation  
    involved_in negative regulation of endothelial cell proliferation  
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of inflammatory response PubMed 
    involved_in negative regulation of lipid biosynthetic process  
    involved_in negative regulation of lipid transport across blood-brain barrier  
    involved_in negative regulation of long-term synaptic potentiation  
    involved_in negative regulation of long-term synaptic potentiation  
    involved_in negative regulation of neuron apoptotic process  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of phospholipid efflux  
    involved_in negative regulation of platelet activation  
    involved_in negative regulation of platelet activation  
    involved_in negative regulation of postsynaptic membrane organization  
    involved_in negative regulation of protein metabolic process  
    involved_in negative regulation of protein secretion  
    involved_in negative regulation of protein secretion  
    acts_upstream_of negative regulation of smooth muscle cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of triglyceride metabolic process PubMed 
    involved_in neuron projection development  
    involved_in nitric oxide-cGMP-mediated signaling  
    involved_in nitric oxide-cGMP-mediated signaling  
    involved_in phospholipid efflux  
    involved_in phospholipid efflux  
    involved_in phospholipid efflux  
    involved_in positive regulation by host of viral process  
    involved_in positive regulation by host of viral process  
    involved_in positive regulation of CoA-transferase activity PubMed 
    involved_in positive regulation of CoA-transferase activity  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of amyloid-beta clearance PubMed 
    involved_in positive regulation of amyloid-beta formation  
    involved_in positive regulation of axon extension  
    involved_in positive regulation of cholesterol efflux PubMed 
    involved_in positive regulation of cholesterol efflux  
    involved_in positive regulation of cholesterol metabolic process PubMed 
    involved_in positive regulation of cholesterol metabolic process  
    involved_in positive regulation of dendritic spine development  
    acts_upstream_of_or_within positive regulation of dendritic spine development  
    involved_in positive regulation of dendritic spine maintenance  
    acts_upstream_of_or_within positive regulation of dendritic spine maintenance  
    involved_in positive regulation of endocytosis  
    involved_in positive regulation of endocytosis  
    involved_in positive regulation of heparan sulfate proteoglycan binding  
    involved_in positive regulation of lipid biosynthetic process  
    involved_in positive regulation of lipid biosynthetic process  
    involved_in positive regulation of lipid transport across blood-brain barrier  
    involved_in positive regulation of lipid transport across blood-brain barrier  
    involved_in positive regulation of lipoprotein transport  
    involved_in positive regulation of low-density lipoprotein particle receptor catabolic process  
    involved_in positive regulation of low-density lipoprotein particle receptor catabolic process  
    involved_in positive regulation of membrane protein ectodomain proteolysis  
    involved_in positive regulation of membrane protein ectodomain proteolysis  
    involved_in positive regulation of neurofibrillary tangle assembly  
    involved_in positive regulation of neuron projection development PubMed 
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of phospholipid efflux  
    involved_in positive regulation of phospholipid efflux  
    involved_in positive regulation of presynaptic membrane organization  
    involved_in protein import  
    NOT acts_upstream_of_or_within protein localization PubMed 
    involved_in receptor-mediated endocytosis  
    involved_in receptor-mediated endocytosis  
    involved_in regulation of Cdc42 protein signal transduction  
    involved_in regulation of Cdc42 protein signal transduction  
    involved_in regulation of amyloid fibril formation  
    involved_in regulation of amyloid precursor protein catabolic process  
    involved_in regulation of amyloid-beta clearance  
    involved_in regulation of apoptotic process PubMed 
    involved_in regulation of behavioral fear response  
    involved_in regulation of behavioral fear response  
    involved_in regulation of cellular response to very-low-density lipoprotein particle stimulus  
    involved_in regulation of cellular response to very-low-density lipoprotein particle stimulus  
    involved_in regulation of cholesterol metabolic process  
    acts_upstream_of_or_within regulation of gene expression PubMed 
    involved_in regulation of innate immune response PubMed 
    involved_in regulation of plasma lipoprotein particle levels PubMed 
    involved_in regulation of proteasomal protein catabolic process  
    involved_in regulation of proteasomal protein catabolic process  
    involved_in regulation of protein metabolic process  
    involved_in regulation of protein-containing complex assembly  
    involved_in regulation of protein-containing complex assembly  
    involved_in regulation of synapse organization PubMed 
    involved_in regulation of synapse organization PubMed 
    involved_in regulation of triglyceride metabolic process  
    involved_in response to caloric restriction  
    involved_in response to caloric restriction  
    acts_upstream_of_or_within response to dietary excess PubMed 
    acts_upstream_of_or_within response to oxidative stress PubMed 
    involved_in reverse cholesterol transport  
    involved_in reverse cholesterol transport  
    involved_in triglyceride homeostasis PubMed 
    involved_in triglyceride metabolic process  
    involved_in triglyceride metabolic process  
    involved_in triglyceride-rich lipoprotein particle clearance PubMed 
    involved_in triglyceride-rich lipoprotein particle clearance  
    involved_in triglyceride-rich lipoprotein particle clearance  
    acts_upstream_of_or_within vasodilation PubMed 
    involved_in very-low-density lipoprotein particle clearance  
    involved_in very-low-density lipoprotein particle clearance  
    involved_in very-low-density lipoprotein particle remodeling PubMed 
    involved_in very-low-density lipoprotein particle remodeling  
    involved_in virion assembly  
    involved_in virion assembly  
    Items 1 - 25 of 184
    Items 1 - 20 of 49
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in cell surface  
    part_of chylomicron  
    part_of chylomicron  
    part_of chylomicron remnant  
    part_of chylomicron remnant  
    located_in cytosol  
    located_in dendrite  
    part_of discoidal high-density lipoprotein particle  
    located_in early endosome  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endosome  
    located_in extracellular exosome  
    located_in extracellular exosome  
    located_in extracellular matrix  
    located_in extracellular matrix  
    located_in extracellular region  
    located_in extracellular region  
    located_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in extracellular vesicle  
    located_in extrinsic component of external side of plasma membrane  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    part_of high-density lipoprotein particle  
    part_of high-density lipoprotein particle  
    part_of high-density lipoprotein particle  
    part_of intermediate-density lipoprotein particle  
    part_of intermediate-density lipoprotein particle  
    located_in late endosome  
    part_of lipoprotein particle  
    part_of low-density lipoprotein particle  
    part_of low-density lipoprotein particle PubMed 
    part_of low-density lipoprotein particle  
    located_in melanosome  
    located_in melanosome  
    located_in microtubule  
    located_in multivesicular body, internal vesicle  
    located_in multivesicular body, internal vesicle  
    located_in neuronal cell body  
    located_in nuclear envelope  
    located_in synaptic cleft  
    is_active_in synaptic cleft  
    part_of very-low-density lipoprotein particle  
    part_of very-low-density lipoprotein particle  
    part_of very-low-density lipoprotein particle  
    Items 1 - 20 of 49

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305819.1NP_001292748.1  apolipoprotein E precursor

      See identical proteins and their annotated locations for NP_001292748.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AI836733, AK134921, DN173921
      Consensus CDS
      CCDS20912.1
      UniProtKB/Swiss-Prot
      P08226
      UniProtKB/TrEMBL
      Q3TXU4, Q3UBS0, Q6GTX3
      Related
      ENSMUSP00000133371.2, ENSMUST00000173739.8
      Conserved Domains (1) summary
      pfam01442
      Location:78280
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    2. NM_001305843.1NP_001292772.1  apolipoprotein E precursor

      See identical proteins and their annotated locations for NP_001292772.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC149282, AI836733, AK134921, BY313639, BY772289
      Consensus CDS
      CCDS20912.1
      UniProtKB/Swiss-Prot
      P08226
      UniProtKB/TrEMBL
      Q3TXU4, Q3UBS0, Q6GTX3
      Conserved Domains (1) summary
      pfam01442
      Location:78280
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    3. NM_001305844.1NP_001292773.1  apolipoprotein E precursor

      See identical proteins and their annotated locations for NP_001292773.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC149282, AI836733, AK134921
      Consensus CDS
      CCDS20912.1
      UniProtKB/Swiss-Prot
      P08226
      UniProtKB/TrEMBL
      Q3TXU4, Q3UBS0, Q6GTX3
      Conserved Domains (1) summary
      pfam01442
      Location:78280
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    4. NM_009696.4NP_033826.2  apolipoprotein E precursor

      See identical proteins and their annotated locations for NP_033826.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AI836733, AK134921, BY313639, BY772289
      Consensus CDS
      CCDS20912.1
      UniProtKB/Swiss-Prot
      P08226
      UniProtKB/TrEMBL
      Q3TXU4, Q3UBS0, Q6GTX3
      Related
      ENSMUSP00000133302.2, ENSMUST00000174064.9
      Conserved Domains (1) summary
      pfam01442
      Location:78280
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19430169..19434326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242015.2XP_030097875.1  apolipoprotein E isoform X1

      UniProtKB/Swiss-Prot
      P08226
      UniProtKB/TrEMBL
      Q3TXU4, Q3UBS0, Q6GTX3
      Conserved Domains (1) summary
      pfam01442
      Location:78280
      Apolipoprotein; Apolipoprotein A1/A4/E domain
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