ROG3 Rog3p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ROG3
Official Full Name: Rog3p
Primary source: SGD:S000001918
Locus tag: YFR022W
See related: AllianceGenome:SGD:S000001918; FungiDB:YFR022W; VEuPathDB:YFR022W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ART7
Summary: Enables ubiquitin protein ligase binding activity. Involved in cellular response to pheromone; conjugation with cellular fusion; and positive regulation of receptor internalization. Located in cytosol. Orthologous to several human genes including ARRDC1 (arrestin domain containing 1); ARRDC2 (arrestin domain containing 2); and ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Data shows that Rog3 is required for Ste2 efficient internalization.
Title: Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to pheromone	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in conjugation with cellular fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor internalization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ubiquitin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_116677.3

Alpha-arrestin involved in ubiquitin-dependent endocytosis; contributes to desensitization of agonist-occupied alpha-factor receptor Ste2p by Rsp5p-independent internalization; PPXY motif-mediated binding of the ubiquitin ligase Rsp5p is not required for adaptation; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; SWAT-GFP and mCherry fusion proteins localize to the cytosol; ROG3 has a paralog, ROD1, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain