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    DHX58 DExH-box helicase 58 [ Homo sapiens (human) ]

    Gene ID: 79132, updated on 9-Dec-2024

    Summary

    Official Symbol
    DHX58provided by HGNC
    Official Full Name
    DExH-box helicase 58provided by HGNC
    Primary source
    HGNC:HGNC:29517
    See related
    Ensembl:ENSG00000108771 MIM:608588; AllianceGenome:HGNC:29517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LGP2; RLR-3; D11LGP2; D11lgp2e
    Summary
    Enables several functions, including ATP hydrolysis activity; RNA binding activity; and zinc ion binding activity. Involved in negative regulation of type I interferon production and regulation of innate immune response. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 10.6), testis (RPKM 8.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DHX58 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42101411..42112714, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42957915..42969232, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40253429..40264732, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:40168666-40169865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8510 Neighboring gene NFKB inhibitor interacting Ras like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12182 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40180775-40181563 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 17 open reading frame 113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40203397-40203898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40214064-40214654 Neighboring gene Sharpr-MPRA regulatory region 8946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8513 Neighboring gene Sharpr-MPRA regulatory region 13373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40220039-40220539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40223445-40224418 Neighboring gene Sharpr-MPRA regulatory region 2167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40256421-40257354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40257355-40258286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40259930-40260442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40267799-40268334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40275137-40275674 Neighboring gene lysine acetyltransferase 2A Neighboring gene heat shock protein family B (small) member 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of DEXH (Asp-Glu-X-His) box polypeptide 58 (DHX58) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic pattern recognition receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoplasmic pattern recognition receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of MDA-5 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of RIG-I signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of RIG-I signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of RIG-I signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MDA-5 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of RIG-I signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of type I interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DHX58
    Names
    ATP-dependent helicase LGP2
    DEXH (Asp-Glu-X-His) box polypeptide 58
    RIG-I-like receptor 3
    RIG-I-like receptor LGP2
    RLR
    RNA helicase LGP2
    ortholog of mouse D11lgp2
    probable ATP-dependent RNA helicase DHX58
    probable ATP-dependent helicase LGP2
    protein D11Lgp2 homolog
    NP_077024.2
    XP_047292680.1
    XP_047292681.1
    XP_047292682.1
    XP_047292683.1
    XP_054173139.1
    XP_054173140.1
    XP_054173141.1
    XP_054173142.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024119.3NP_077024.2  ATP-dependent RNA helicase DHX58

      See identical proteins and their annotated locations for NP_077024.2

      Status: VALIDATED

      Source sequence(s)
      AK021416, BC014949
      Consensus CDS
      CCDS11416.1
      UniProtKB/Swiss-Prot
      Q96C10, Q9HAM6
      UniProtKB/TrEMBL
      A0AA51U9C6, B4DV26
      Related
      ENSP00000251642.3, ENST00000251642.8
      Conserved Domains (4) summary
      cd15806
      Location:552664
      LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
      cd12090
      Location:227345
      MDA5_ID; Insert domain of MDA5
      cd18802
      Location:349483
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18075
      Location:1200
      DEXHc_RLR-3; DEXH-box helicase domain of RLR-3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      42101411..42112714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436724.1XP_047292680.1  ATP-dependent RNA helicase DHX58 isoform X1

      UniProtKB/Swiss-Prot
      Q96C10, Q9HAM6
      UniProtKB/TrEMBL
      A0AA51U9C6, B4DV26
    2. XM_047436725.1XP_047292681.1  ATP-dependent RNA helicase DHX58 isoform X1

      UniProtKB/Swiss-Prot
      Q96C10, Q9HAM6
      UniProtKB/TrEMBL
      A0AA51U9C6, B4DV26
    3. XM_047436726.1XP_047292682.1  ATP-dependent RNA helicase DHX58 isoform X2

      UniProtKB/TrEMBL
      B3KUP5, E9PHD3
    4. XM_047436727.1XP_047292683.1  ATP-dependent RNA helicase DHX58 isoform X3

      UniProtKB/TrEMBL
      C9JG98
      Related
      ENSP00000416389.1, ENST00000413196.6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      42957915..42969232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317164.1XP_054173139.1  ATP-dependent RNA helicase DHX58 isoform X1

      UniProtKB/Swiss-Prot
      Q96C10, Q9HAM6
      UniProtKB/TrEMBL
      A0AA51U9C6, B4DV26
    2. XM_054317165.1XP_054173140.1  ATP-dependent RNA helicase DHX58 isoform X1

      UniProtKB/Swiss-Prot
      Q96C10, Q9HAM6
      UniProtKB/TrEMBL
      A0AA51U9C6, B4DV26
    3. XM_054317166.1XP_054173141.1  ATP-dependent RNA helicase DHX58 isoform X2

      UniProtKB/TrEMBL
      B3KUP5, E9PHD3
    4. XM_054317167.1XP_054173142.1  ATP-dependent RNA helicase DHX58 isoform X3

      UniProtKB/TrEMBL
      C9JG98